SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Disease: Alexander Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270726
Disease: Alexander Disease
Alexander Disease 		0.010 Biomarker disease BEFREE This result, in addition to our previous works in which we documented that ceftriaxone interacts with α-synuclein inhibiting its pathological aggregation and that a cyclical treatment with this molecule in a patient with adult-onset Alexander's disease halted, and partly reversed, the progression of neurodegeneration, suggests the possibility of a chaperone-like effect of ceftriaxone on protein involved in specific neurodegenerative diseases. 27133445 2016