Autosomal Dominant Parkinsonism
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
SNCA mutations cause autosomal dominant parkinsonism and inform our understanding of the molecular underpinnings of synucleinopathies.
|
30423204 |
2018 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.
|
27324791 |
2017 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.
|
26687234 |
2016 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease.
|
27026137 |
2016 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.
|
26075822 |
2015 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells.
|
26558463 |
2015 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism.
|
23046578 |
2013 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats.
|
23295396 |
2013 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.
|
22319455 |
2012 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
CTD_human |
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.
|
20464527 |
2010 |
Autosomal Dominant Parkinsonism
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In addition, the co-expression of Cu/Zn superoxid dismutase protects against the dopaminergic neuronal loss induced by mutant alpha-synuclein overexpression thus identifying oxidative stress as an important causative factor in the pathology of autosomal-dominant Parkinsonism.
|
18243716 |
2008 |
Autosomal Dominant Parkinsonism
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We screened 50 probands of families with autosomal dominant parkinsonism for alpha-synuclein mutations by exon sequencing.No known or novel mutations were found.
|
15308306 |
2004 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
BEFREE |
Analysis of alpha-synuclein, parkin, tau, and UCH-L1 in a Japanese family with autosomal dominant parkinsonism.
|
11455179 |
2001 |
Autosomal Dominant Parkinsonism
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In the same year, from the identification of mutation in the alpha-synuclein gene in rare pedigrees with autosomal dominant parkinsonism, arose the concept that Parkinson's disease may be part of a broader group of 'synucleinopathies', in which there is a fundamental defect in protein processing.
|
12378057 |
2001 |
Autosomal Dominant Parkinsonism
|
0.370 |
Biomarker
|
disease |
BEFREE |
The co-localization of NACP/alpha-synuclein and tau epitopes was examined in the brain stem and hippocampal formation in two patients from a family of autosomal dominant parkinsonism and dementia with Lewy bodies (LBs) without two reported missense mutations in the NACP gene.
|
10963357 |
2000 |
Autosomal Dominant Parkinsonism
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
A specific mutation (A53T) in the encoding region for alpha-synuclein has been identified in a large multigenerational family with an autosomal dominant parkinsonism known as the Contursi kindred.
|
9878203 |
1998 |