SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1868596
Disease: Atypical Parkinson Disease
Atypical Parkinson Disease
0.210 GeneticVariation disease BEFREE Genetic atypical Parkinson's disease (PD) describes monogenic forms of PD that resemble idiopathic PD but feature prominent atypical clinical signs and symptoms and can be sub-grouped into i) atypical monogenic forms caused by mutations in the ATP13A2, DNAJC6, FBXO7, SYNJ1, VPS13C, and DCTN genes; ii) monogenic PD more closely resembling idiopathic PD, but associated with atypical features in at least a subset of cases (SNCA-, LRRK2-, VPS35-, Parkin-, PINK1-, and DJ-1-linked PD; iii) carriers of mutations in genes that are usually associated with other movement disorders but may present with parkinsonism, such as dopa-responsive dystonia. 31779813 2019
CUI: C1868596
Disease: Atypical Parkinson Disease
Atypical Parkinson Disease
0.210 Biomarker disease MGD Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. 18622040 2008
CUI: C1868596
Disease: Atypical Parkinson Disease
Atypical Parkinson Disease
0.210 Biomarker disease MGD Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. 10707987 2000