Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
SMN deficiency causes neurodegenerative disease spinal muscular atrophy (SMA).
|
31799625 |
2020 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduced expression of the survival motor neuron (SMN) protein causes the neurodegenerative disease spinal muscular atrophy (SMA).
|
31851921 |
2019 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Ubiquitous deficiency in the survival motor neuron (SMN) protein causes death of motor neurons-a hallmark of the neurodegenerative disease spinal muscular atrophy (SMA)-through poorly understood mechanisms.
|
30012555 |
2018 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that results from mutations in the SMN1 gene, leading to survival motor neuron (SMN) protein deficiency.
|
29103974 |
2017 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by alpha motor neuron loss in the spinal cord due to reduced survival motor neuron (SMN) protein level.
|
28635376 |
2017 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Low levels of the survival of motor neuron (SMN) protein cause the neurodegenerative disease spinal muscular atrophy (SMA).
|
28852871 |
2017 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The childhood neurodegenerative disease spinal muscular atrophy (SMA) is caused by loss-of-function mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene resulting in insufficient levels of survival motor neuron (SMN) protein.
|
28069797 |
2017 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The reduced level of survival motor neuron (SMN) protein, caused by homozygous deletions in the SMN gene, led to a common neurodegenerative disorder known as spinal muscular atrophy (SMA).
|
26331341 |
2016 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is an inherited childhood neurodegenerative disorder caused by ubiquitous deficiency of the survival motor neuron (SMN) protein - the hallmarks of which are the selective loss of motor neurons and skeletal muscle atrophy.
|
27472505 |
2016 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Spinal muscular atrophy (SMA), a heritable neurodegenerative disease, results from insufficient levels of the survival motor neuron (SMN) protein.
|
26464491 |
2015 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The survival motor neuron (SMN) protein is key to this biological paradigm: SMN is essential for the biogenesis of various RNPs that function in mRNA processing, and genetic mutations leading to SMN deficiency cause the neurodegenerative disease spinal muscular atrophy.
|
24769255 |
2014 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development.
|
24590288 |
2014 |
Neurodegenerative Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The clinical severity of the neurodegenerative disorder spinal muscular atrophy (SMA) is dependent on the levels of functional Survival Motor Neuron (SMN) protein.
|
23757500 |
2013 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN) protein.
|
24332368 |
2013 |
Neurodegenerative Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease associated with low levels of the essential survival motor neuron (SMN) protein.
|
22763238 |
2012 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Spinal muscular atrophy (SMA), a frequent neurodegenerative disease, is caused by reduced levels of functional survival of motoneuron (SMN) protein.
|
21920940 |
2011 |
Neurodegenerative Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Proximal spinal muscular atrophy (SMA) is a neurodegenerative disease caused by low levels of the survival motor neuron (SMN) protein.
|
20705738 |
2010 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In contrast to other neurodegenerative disorders, SMA is a genetically homozygous autosomal recessive disease that is caused by deficiency of the survival motor neuron (SMN) protein.
|
20581815 |
2010 |
Neurodegenerative Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Spinal muscular atrophy (SMA) is a neurodegenerative disorder associated with mutations of the survival motor neuron gene SMN and is characterized by muscle weakness and atrophy caused by degeneration of spinal motor neurons.
|
19351384 |
2009 |
Neurodegenerative Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The survival of motor neurons (SMN) protein, the product of the neurodegenerative disease spinal muscular atrophy (SMA) gene, is localized both in the cytoplasm and in discrete nuclear bodies called gems.
|
10725331 |
2000 |