SOD1, superoxide dismutase 1, 6647

N. diseases: 689; N. variants: 68
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 GeneticVariation disease BEFREE Mice that are deficient in superoxide dismutase 1 (Sod1), an antioxidative enzyme, are susceptible to developing liver steatosis. 30050648 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease CTD_human Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis. 27349771 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 GeneticVariation disease BEFREE Mice with defects in the SOD1 or Lepr gene are vulnerable to developing fatty livers, even when fed a normal diet. 27855316 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 AlteredExpression disease BEFREE These results suggest that TSIIA attenuates oxidative stress by decreasing ROS and MDA production and enhancing the activity of T-SOD and GSH-PX, which may contribute to the inhibition of apoptosis and amelioration of liver steatosis. 29201162 2017