SOD1, superoxide dismutase 1, 6647

N. diseases: 689; N. variants: 68
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 GeneticVariation phenotype BEFREE Intermediate-term spatial memory was impaired in SOD1 <sup>G93A</sup> females, whereas long-term spatial memory deficits as well as lower acoustic startle response, and prepulse inhibition were identified in SOD1 <sup>G93A</sup> mice of both sexes compared with respective controls. 31412164 2020
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 AlteredExpression phenotype BEFREE Our analyses indicated that luteoline had a significant effect on decreasing the contents of ROS and MDA, elevating the activity of SOD, and ultimately improving spatial learning and memory deficits of mice. 31006528 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 AlteredExpression phenotype BEFREE Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. 27834214 2016
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 Biomarker phenotype BEFREE Here, we show that Sod1 deficiency in an amyloid precursor protein-overexpressing mouse model (AD mouse, Tg2576) accelerated Aβ oligomerization and memory impairment as compared with control AD mouse and that these phenomena were basically mediated by oxidative damage. 22072713 2011