SOX4, SRY-box transcription factor 4, 6659

N. diseases: 246; N. variants: 1
Disease: Squamous cell carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 AlteredExpression disease BEFREE MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4. 31059001 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 Biomarker disease BEFREE We demonstrate that miR-31 is significantly decreased in invasive esophageal cancer cells, while upregulation of miR-31 inhibits growth, migration and invasion of esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC) cell lines. miR-31, in turn, targets SOX4 for degradation by directly binding to its 3'-UTR. 25644061 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 AlteredExpression disease BEFREE SOX4 expression is associated with treatment failure and chemoradioresistance in oral squamous cell carcinoma. 26555193 2015