Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SOX11 negative leukemic non-nodal mantle cell lymphomas were also negative by RNAscope.
|
31296581 |
2020 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of SOX11 mRNA was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and the relationship of survival with SOX11 mRNA and MIPI in MCL patients was evaluated.
|
31646825 |
2020 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, our data revealed a potential inverse relationship between phosphorylated Y705 STAT3 and SOX11 expression in MCL cell lines, primary tumors, and patient-derived xenografts.
|
30530749 |
2019 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, SOX11-negative MCL is characterized by more frequent leukemic non-nodal disease, classic morphology, more frequent expression of CD23 and CD200, and a lower Ki67 index.
|
30768440 |
2019 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SOX11-positive MCL showed a significant higher microvascular development than negative tumours (median MVA = 14.5 × 10<sup>-3</sup> versus 5.0 × 10<sup>-3</sup> P < 0.001; median MVD = 18.6/μm<sup>2</sup> versus 14.2/μm<sup>2</sup> , P = 0.021).
|
31173643 |
2019 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the diagnostic accuracy of SOX11 immunohistochemistry for the diagnosis of MCL using a meta-analysis.
|
31714947 |
2019 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL).
|
30221780 |
2019 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX11 is a transcription factor that plays an important role in mantle cell lymphoma development.
|
30922366 |
2019 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the variable region of immunoglobulin heavy chain, methylation status, and SOX-11 expression.
|
30963600 |
2019 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clinically, the nonnodal MCL subset is notable for leukemic presentation, indolent behavior, and association with hypermutated IGHV and lack of SOX11 expression, which differentiates it from the conventional nodal MCL.
|
31808882 |
2019 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A database search showed that SOX11, a crucial transcription factor in MCL, is the putative target of miR-223.
|
29158064 |
2018 |
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have measured MRD level in follow-up samples from 27 patients diagnosed with MCL using the molecular markers: t(11;14), IGH rearrangement and SOX11 expression.
|
29520657 |
2018 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL.
|
29615403 |
2018 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulated SOX11 may be a good prognostic factor in MCL patients.
|
29771407 |
2018 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 and SOX11 only stain the central portion that represents MCL and LEF-1 stains the periphery that represents CLL/SLL.
|
28109040 |
2018 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SOX11 is a relevant element in the pathogenesis of MCL and has been instrumental to identify two distinct clinicobiological subtypes of this tumor.
|
29738333 |
2018 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conducted immunohistochemical staining of C-MYC, Programmed cell death ligand 1 (PD-L1), CD8, Ki-67, p53 and SRY (sex determining region Y) -11 (SOX11) to investigate their expression in 64 patients with MCL.
|
28626618 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In intravenous MCL xenograft models, SOX11<sup>+</sup> MCL cells display higher cell migration, invasion, and growth compared with SOX11-knockdown cells, and specific FAK and CXCR4 inhibitors impair SOX11-enhanced MCL engraftment in bone marrow.
|
28533307 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The absence of SOX-11 or a low Ki-67 may correlate with a more indolent form of MCL.
|
28699667 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To this end, since little data are available in the literature, four commercially available anti-SOX11 antibodies (two polyclonal and two monoclonal) were tested on 21 positive staging bone marrow (BM) biopsies from cyclin D1/SOX11-positive MCL patients (17 fixed in B5, 4 in 10% buffered formalin) and on 9 positive BM biopsies from leukemic non-nodal MCL patients.
|
27720733 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent data have revealed the potential oncogenic role of SOX11 in MCL biology, highlighting its implication in tumor aggressiveness and progression.
|
28466437 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conclusively, our data suggest that SOX11 represents a useful prognostic marker in mantle cell lymphoma.
|
28429312 |
2017 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11.
|
27846393 |
2016 |
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, recent data show that the neural transcription factor SOX11 is a disease defining antigen and several involved signaling pathways have been pin-pointed, among others the Wnt/β-catenin pathway that is of importance for proliferation in MCL.
|
27430213 |
2016 |
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology.
|
26998831 |
2016 |