Disease: Gingival Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017563
Disease: Gingival Diseases
Gingival Diseases 		0.010 Biomarker group BEFREE Lipid A of ΔPGN_1123 mutants is penta-acylated and devoid of tetra-acylated structures, and the mutant strain provokes a strong TLR4-mediated proinflammatory response, in contrast to the negligible response elicited by wild-type <i>P. gingivalis</i> Heterologous expression of PGN_1123 in <i>Bacteroides thetaiotaomicron</i> promoted lipid A deacylation, confirming that PGN_1123 encodes the lipid A deacylase enzyme.<b>IMPORTANCE</b> Periodontitis, commonly referred to as gum disease, is a chronic inflammatory condition that affects a large proportion of the population. 30782639 2019