Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The SPINK1 c.194 + 2T > C variant is a strong risk factor for CP, especially in East Asian patients with ICP.
|
31401021 |
2020 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe the case of a middle-aged male who presented with recurrent pancreatitis in the setting of the serine peptidase inhibitor, Kazal type 1 (SPINK-1) genetic polymorphism.
|
30891392 |
2019 |
Pancreatitis, Chronic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Having a variant from CFTR, SPINK1 or PRSS1, was associated with the faster progression from AP to CP over time (p < 0.05).
|
31088717 |
2019 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The clinical significance of SPINK1 intronic variants in chronic pancreatitis has been previously assessed by various approaches including a cell culture-based full-length gene assay.
|
30755276 |
2019 |
Pancreatitis, Chronic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The primary aim of this study was to determine the blood levels of SPINK1 in patients with chronic pancreatitis (CP) submitted to surgical or endoscopic decompression of pancreatic duct (PD).
|
29525377 |
2018 |
Pancreatitis, Chronic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutations, especially those in PRSS1, SPINK1, and CFTR, accounted for the major etiologies in Chinese children with CP or ARP.
|
29173301 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On multivariate analysis idiopathic etiology (p<0.03), presence of SPINK1 mutation (p=0.01), longer follow-up (p<0.001) were associated with progression to CP.
|
28320629 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Those preliminary data suggest low prevalence of SPINK1 and PRSS1 mutations in the Chinese population, generally, as well as in CP patients, indicating that these mutations do not contribute to the development of CP.
|
29641165 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe a case of malignant pancreatic cancer diagnosed in a young patient with chronic pancreatitis who is a SPINK 1 heterozygote gene mutation carrier.
|
27358244 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SPINK1 (serine protease inhibitor, kazal-type, 1), which encodes human pancreatic secretory trypsin inhibitor, is one of the most extensively studied genes underlying chronic pancreatitis.
|
28472998 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association between SPINK1 p.N34S gene variation and CP is confirmed.
|
28546062 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to identify pathogenic SPINK1 promoter variants associated with chronic pancreatitis (CP).
|
26348468 |
2016 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown.
|
27845447 |
2016 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ethnicity and mutations in PRSS1 or SPINK1 may influence the development of CP.
|
27064572 |
2016 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In India, RAP and CP have been associated with SPINK1 polymorphism.
|
26110235 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study lends further support to the notion that sequence evaluation of the SPINK1 promoter region in patients with chronic pancreatitis is justified as part of the etiological investigation.
|
25792561 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Some TATI mutations predict susceptibility to recurrent or chronic pancreatitis.
|
24583226 |
2014 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the cationic trypsinogen (PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal type 1 (SPINK1), and chymotrypsin C (CTRC) genes are associated with an elevated risk for chronic pancreatitis, which is a known risk factor for pancreatic cancer (PC).
|
25003218 |
2014 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four patients had hereditary pancreatitis (three with confirmed N34S mutation in the SPINK1 gene), one patient had chronic pancreatitis of unknown etiology, and one patient with annular pancreas developed obstructive chronic pancreatitis.
|
24210198 |
2013 |
Pancreatitis, Chronic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Surgical specimens of pancreatic ductal adenocarcinoma (n = 23), intraductal papillary mucinous neoplasm (IPMN;n = 21), pancreatic neoplasms other than ductal adenocarcinoma (n = 8), chronic pancreatitis (n = 11), and pancreatic intraepithelial neoplasia (PanIN) lesions within the resected specimens were analyzed immunohistochemically for SPINK1 and EGFR expression.
|
23475261 |
2013 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes encoding cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) are associated with chronic pancreatitis.
|
24260417 |
2013 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The N34S mutation of the SPINK1 gene seems to be significantly correlated with alcoholic chronic pancreatitis.
|
22751291 |
2012 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis.
|
22699143 |
2012 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in three genes, the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene and the pancreatic secretory trypsin inhibitor (SPINK1) gene, have been identified as risk factors for CP.
|
22109105 |
2012 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies have shown an association between SPINK1 gene variants and chronic pancreatitis or recurrent acute pancreatitis.
|
22526274 |
2012 |