|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
BEFREE |
In the present study, the effect of copper substitution into β-TCP crystal structure on the local chemical structure and dissolution property of the copper-doped β-TCP (CuTCP) was investigated to clarify the dissolution mechanism of β-TCP.
|
31034946 |
2019 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
BEFREE |
β-TCP (Ca3(PO4)2) synthesized from abalone shell can be used as a potential source of bone grafting material.
|
28157816 |
2017 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
BEFREE |
This approach allowed us to identify five TFs belonging to three distinct TF families: one TCP (OsPCF2), one CPP (OsCPP5) and three NIN-like (OsNIN-like2, OsNIN-like3 and OsNIN-like4) binding to the OsNHX1 gene promoter.
|
27766460 |
2017 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the galvanic action of silver particles dispersed in the iron phase significantly accelerated in vitro degradation of β-TCP-30(Fe-Ag) nanocomposites.
|
28576063 |
2017 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
BEFREE |
In a previous study, the authors have shown that rather than variants in trypsinogen gene(s), mutations in pancreatic secretory trypsin inhibitor (encoded by SPINK1) and cathepsin B (CTSB) are associated with tropical calcific pancreatitis (TCP).
|
22580415 |
2013 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
N34S SPINK1 represents the major genetic risk factor in TCP.
|
19077465 |
2009 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The SPINK1 variant p.N34S is strongly associated with TCP, but other genetic factors remain to be defined.
|
19404200 |
2009 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant association of the SNPs was observed with TCP or FCPD or between carriers and non-carriers of N34S SPINK1 and L26V CTSB mutations.
|
18706099 |
2008 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Indeed, alterations in at least two genes, SPINK1 and CTRC, are strongly associated with TCP.
|
18604651 |
2008 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis.
|
17990360 |
2007 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in pancreatic secretory trypsin inhibitor (SPINK1) rather than cationic trypsinogen (PRSS1) explain the disease in only 50% of TCP patients.
|
16492714 |
2006 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
However, mutated SPINK1 does not account for the disease in all the patients, neither does it explain the phenotypic heterogeneity between TCP and fibro-calculous pancreatic diabetes (FCPD).
|
17163998 |
2006 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
BEFREE |
In a syngenic WAG/Rij rat model, the combination of AdTCPtk/GCV treatment with administration of murine interleukin-12 (mIL-12) expressing adenovirus under control of TCP (AdTCPmIL-12) resulted in effective growth suppression of tumor at the treated site and also at a distant untreated site, in comparison to treatment with AdTCPtk/GCV or AdTCPmIL-12 alone.
|
14681722 |
2004 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
SusceptibilityMutation
|
disease |
ORPHANET |
In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP.
|
12360463 |
2002 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP.
|
12360463 |
2002 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis.
|
12011155 |
2002 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent.
|
12187509 |
2002 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
SusceptibilityMutation
|
disease |
ORPHANET |
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis.
|
12011155 |
2002 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
TROPICAL CALCIFIC PANCREATITIS
|
0.800 |
Biomarker
|
disease |
CTD_human |
|
|
|