SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Disease: West Nile Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043124
Disease: West Nile Fever
West Nile Fever 		0.020 AlteredExpression disease BEFREE Our data suggests that OPN expression at early time points may provide protection against viral spread in the CNS by negatively controlling the type I IFN-sensitive, caspase 1-dependent inflammasome, while promoting an alternative caspase 8-associated pathway, to control the apoptosis of infected cells during WNV infection in the CNS. 28811681 2017
CUI: C0043124
Disease: West Nile Fever
West Nile Fever 		0.020 Biomarker disease BEFREE Interestingly, WNV-infected OPN deficient (Opn <sup>-/-</sup>) mice exhibited a higher survival rate (70%) than wild type (WT) control mice (30%), suggesting OPN plays a deleterious role in WNV infection. 28680095 2017