|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
RASSF1A restricts SRC activity, preventing motility, invasion, and tumorigenesis in vitro and in vivo, with epigenetic inactivation correlating with increased inhibitory pY527-SRC in breast tumors.
|
26549256 |
2015 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Src: a potential target for the treatment of triple-negative breast cancer.
|
21357651 |
2011 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In agreement with this phenotype, SRC-1 expression positively correlated with integrin α(5) (ITGA5) expression in estrogen receptor-negative breast tumors whereas SRC-1 deficiency decreased ITGA5 expression.
|
21343398 |
2011 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our data link the SMRT corepressor directly with SRC family coactivators in positive regulation of ERalpha-dependent gene expression and, taken with the positive correlation found for SMRT and SRC-3 in human breast tumors, suggest that SMRT can promote ERalpha- and SRC-3-dependent gene expression in breast cancer.
|
20392877 |
2010 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Importantly, overexpression of SRC-3Delta4 promotes MDA-MB231-induced breast tumor metastasis.
|
20159552 |
2010 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.
|
18550772 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR.
|
17849451 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.
|
16377083 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer.
|
16412380 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Role of c-Src in human MCF7 breast cancer cell tumorigenesis.
|
16728403 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Fibronectin and type IV collagen activate ERalpha AF-1 by c-Src pathway: effect on breast cancer cell motility.
|
15467744 |
2004 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways.
|
12907754 |
2003 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells.
|
12216109 |
2002 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Using quantitative RT-PCR, we, therefore, measured the levels of transcripts encoding these coregulators, as well as the corepressor SMRT, and the coactivator SRC-1, in a small cohort of tamoxifen-resistant and sensitive breast tumors.
|
11108862 |
2001 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transgenic mouse models of mammary tumorigenesis and analyses of human breast tumour samples have indicated a role for Src proteins in the tumorigenic process.
|
9531474 |
1998 |