SRD5A2, steroid 5 alpha-reductase 2, 6716

N. diseases: 106; N. variants: 55
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE The result showed that there was no relationship between the V89L polymorphism of the SRD5A2 gene (V/V versus V/L + L/L genotypes) and breast cancer susceptibility (OR = 1.21; 95%CI = 0.99-1.47; P = 0.28). 26345832 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations. 24365257 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 Biomarker disease BEFREE Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. 15212687 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 AlteredExpression disease BEFREE The Leu allele has been associated with lower SRD5A2 activity and might be protective for breast cancer. 14652280 2003
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE This study is the first to our knowledge focusing on Japanese women, suggesting that SRD5A2 polymorphisms might have an association with breast cancer risk. 12100746 2002