|
Neoplasms
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results suggest that a potential tumor suppressor gene(s) may reside in the < 2 Mb region centromeric (inclusive) to the BRCA1 gene and that this tumor suppressor gene(s) may be involved in the formation of prostate cancer.
|
7478543 |
1995 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We have thus excluded THRA1 as a commonly mutated sporadic breast cancer tumor suppressor gene and as the BRCA1 gene.
|
7511052 |
1994 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These data are consistent with the hypothesis that BRCA1 mutations are involved in the etiology of hereditary ovarian carcinomas but occur rarely in sporadic tumors, and that the frequent allelic loss on chromosome 17q in this cancer type reflects the involvement of an additional tumor suppressor gene(s).
|
7606717 |
1995 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Analysis of polymorphic loci on 17q in the series of hybrid clones suggested that a tumor suppressor gene associated with prostate cancer was located in a region no more than 28 cM long at 17q12-q22, which includes the BRCA1 gene involved in hereditary breast cancer.
|
7614477 |
1995 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Our data support a tumour suppressor mechanism for BRCA1; somatic mutations and LOH may result in inactivation of BRCA1 in at least a small number of ovarian cancers.
|
7795652 |
1995 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Thus it is a plausible candidate for a tumor suppressor gene such as BRCA1.
|
7829067 |
1994 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Thus, our results provide functional evidence for the presence of one or more tumor suppressor gene(s) on chromosome 17, which are distinct from the p53 and the BRCA1 genes.
|
7845668 |
1995 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These data are consistent with a tumour suppressor model, and support the notion that this candidate gene is in fact BRCA1.
|
7894491 |
1994 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors.
|
7939630 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
These results suggest that a potential tumor-suppressor gene involved in both sporadic and familial ovarian cancer may reside on the distal portion of chromosome 17q and is distinct from the BRCA1 gene.
|
7942844 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
There was loss of the wild-type allele from both maternally and paternally derived chromosomes, therefore excluding the possibility of genomic imprinting and providing further evidence that BRCA1 is a tumor suppressor.
|
7954448 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Loss of heterozygosity in breast and ovarian tumors from BRCA1-linked patients always involved loss of wild-type alleles from chromosome 17q21, suggesting that BRCA1 acts as a tumor suppressor gene.
|
7987831 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Recent data support the hypothesis that BRCA1 is a tumor suppressor gene that may be important in the development of both inherited and sporadic breast and ovarian cancers.
|
8039134 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We have found a low frequency of loss of heterozygosity at this region, and our results do not support the idea that BRCA1 is a tumor suppressor gene.
|
8076936 |
1994 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Loci other than BRCA1 that have been identified appear not only to predispose to breast and/or ovarian tumors, but to tumors at other sites too.
|
8116068 |
1993 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Markers from this map can be used to determine whether cancer is linked to BRCA1 in families, to evaluate whether tumors have lost heterozygosity at loci in the region, and to identify probes for characterizing chromosomal rearrangements from patients and from tumors.
|
8244378 |
1993 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The allel retained in each tumour was from the disease-bearing chromosome implicating BRCA1 as a tumour suppressor gene.
|
8281142 |
1993 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Inhibition of BRCA1 expression in mammary epithelial cell lines also suggests that BRCA1 may act as a tumor suppressor.
|
8541881 |
1995 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The data suggest that the region distal to BRCA1 may contain 1 or more prostate-specific tumor suppressor genes and that BRCA1 itself plays only a minor role in prostate cancer development.
|
8558713 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
This was attributed mainly to nuclear polymorphism (P < 0.0001), mitotic activity (P < 0.0001), and tubular differentiation (P = 0.0004), implying that BRCA1-associated BCs are highly proliferating tumors.
|
8564955 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
As a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products.
|
8589722 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q.
|
8605099 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Losses of BRCA1 markers correlated with larger tumour size, higher grade, and PgR expression.
|
8630282 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
These results suggest that inactivation of the BRCA1 gene may not be responsible for the development of borderline ovarian tumors and that another tumor suppressor gene, located centromeric to the BRCA1 gene, may play a role in sporadic ovarian cancer development.
|
8632895 |
1996 |