|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Sporadic ovarian tumors are the end result of a complex pathway involving multiple oncogenes and tumor suppressor genes, including HER-2/neu, K-ras, p53, BRCA1, and additional tumor suppressor genes on chromosome 17.
|
8634990 |
1995 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
These results provide the first direct biological evidence for the possible function of BRCA1 as a tumor suppressor gene.
|
8637708 |
1996 |
|
Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Normal breast epithelium surrounding the BRCA1 tumors showed higher mRNA levels than the tumor tissue, indicating that the low mRNA levels were due to somatic inactivation of the wild-type BRCA1 allele in the tumor tissue.
|
8674039 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BRCA1 is a putative tumour suppressor gene located on chromosome 17q21.
|
8695765 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BRCA1 is proposed to be a tumor suppressor gene.
|
8698242 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The breast and ovarian cancer susceptibility gene BRCA1, is a nuclear phosphoprotein which functions as a tumor suppressor.
|
8700535 |
1996 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Examples include the RB1 gene for retinoblastoma; the WT1 gene for Wilms' tumor; germline p53 mutations in families with the Li-Fraumeni syndrome; the NF1 and NF2 genes for neuroblastomatosis, types 1 and 2; the VHL gene for renal cancer and other tumors associated with Von Hippel-Lindau disease; the APC gene for adenomatous polyposis coli; the BRCA1 gene for hereditary breast and ovarian cancer; and the mismatch repair genes for colon and other common cancers.
|
8741802 |
1995 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We observed a prevalence of highly proliferating tumors when the mutation occurs in the two terminal conserved domains of the BRCA1 protein, ie., in the amino and carboxyl termini (P = 0.0024).
|
8764110 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BRCA1 has been identified as a tumor suppressor gene that is mutated in many cases of inherited breast and ovarian cancer.
|
8840964 |
1996 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Loss of the wild-type allele in > 90% of tumors from patients with inherited BRCA1 mutations indicates tumor suppressive function.
|
8938427 |
1996 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The BARD1/BRCA1 interaction is disrupted by BRCA1 missense mutations that segregate with breast cancer susceptibility, indicating that BARD1 may be involved in mediating tumour suppression by BRCA1.
|
8944023 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The breast cancer susceptibility gene (BRCA1) has been identified as a putative tumor suppressor on chromosome 17.
|
8957093 |
1996 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BRCA1 is a tumour suppressor gene located on chromosome band 17q21.
|
9115959 |
1997 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
These results suggest that BRCA1-induced breast cancers may manifest distinct tumour biological features of clinical importance.
|
9155518 |
1997 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
All tumors of the patients carrying a mutation of BRCA1 showed deletion of wild-type alleles, implicating BRCA1 as a tumor suppressor gene.
|
9197534 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Tumors from women with BRCA1 mutations were significantly less likely to be estrogen receptor positive (age-adjusted odds ratio [or]: 0.091; P < 0.001) and more likely to have a high nuclear grade (OR: 5.55; P 0.001) than tumors in which no mutation was identified.
|
9241077 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Germline mutations in tumor suppressor genes BRCA1 and p53 are used to illustrate the magnitude of the ethnic differences for breast cancer that might arise from differences in inherited susceptibility.
|
9255577 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Mutations of the BRCA1 gene in tumor DNA from patients with sporadic breast cancer have not yet been observed.
|
9269993 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Firstly, family members of affected patients are likely to carry mutations as well, and should be considered for BRCA1 screening; and secondly, persons harbouring a germline BRCA1 mutation should be examined frequently and indefinitely for new primary tumours in remaining breast tissue.
|
9274454 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Because a normal allele of BRCA1 was retained in the tumor where a germline missense alteration was detected, the heterozygous DNA alteration should not be cancer predisposing in terms of the two-hit model for inactivation of the tumor suppressor gene.
|
9299260 |
1997 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Detailed deletion mapping has localized the potential tumor suppressor loci to a < 2 Mb region centromeric to the BRCA1 gene on chromosome 17q.
|
9321930 |
1997 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
However, whether and how these various factors influence tumor development in BRCA1 mutation carriers is not known.
|
9406579 |
1998 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Tumors from 90 patients were examined for TP53 abnormality and loss of heterozygosity (LOH) at 11 loci on 17q (17q11.2-21) and 13q (13q12-14), including the loci for BRCA1 and BRCA2.
|
9408754 |
1997 |
|
Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Accordingly, BARD1 is likely to be a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers.
|
9425226 |
1998 |
|
Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Presence of germ-line mutations in the BRCA1 gene of these tumors is an infrequent event.
|
9440731 |
1998 |