|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
|
16670339 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13-24 residues long, of Ro52/Ro60 proteins.
|
16356190 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.
|
15916807 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that the expression of Ro52 is significantly increased in PBMC of patients with Sjögren's syndrome and SLE, and demonstrate that Ro52 is a RING-dependent E3 ligase involved in ubiquitination.
|
16670339 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between HLA and SS was restricted to patients with anti-SSA and/or anti-SSB; no association with HLA was observed in patients in group 1 (no antibody).
|
12905478 |
2003 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production.
|
12646630 |
2003 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
As TAP2*Bky2 had a strong linkage disequilibrium with DRB1*08032, TAP2*Bky2 or its haplotype with DRB1*08032 may be involved in SS-A/Ro antibody production not only in SS but also SLE patients, indicating that TAP2*Bky2 may be a susceptible gene not only to the disease of SS but also to the SS-A/Ro autoantibody production.
|
12729048 |
2003 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-gamma inducible tripartite motif protein associated with membrane proximal structures.
|
12047754 |
2002 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies binding the Ro (or SSA) and La (or SBB) proteins are commonly found in a high proportion of sera from patients with systemic lupus erythematosus or Sjögren's syndrome.
|
12410797 |
2002 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings may indicate a role for apoptosis in the induction and facilitation of humoral responses to Ro52, Ro60 and La48 in the autoimmune exocrinopathy of SS.
|
12410795 |
2002 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows that the production of anti-Ro52 autoantibodies in pSS is associated with the DRB1*0301, DRB3*0101, DQA1*0501 and DQB1*0201 alleles which are in strong linkage disequilibrium.
|
11555411 |
2001 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, the incidence of antibodies to SS-56 was associated with visceral complications in SLE, and roughly half of the 17 SS or SLE patients with no detectable antibodies to SSA and SSB antigens presented measurable antibodies against recombinant SS-56.
|
11560955 |
2001 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was a strong correlation between clinical signs and corresponding autoantibodies such as anti-SSA and -SSB antibodies in Sjögren's syndrome (10 cases), antithyroid peroxidase antibodies in thyroiditis and Graves' disease (10 cases), and parietal cell antibodies in gastric ulcers with maltoma (12 cases).
|
10205590 |
1999 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The GSTM1 homozygous null genotype could be a genetic factor that determines susceptibility to SS and may be involved in SSA antibody production.
|
10616008 |
1999 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus.
|
9125110 |
1997 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant 52 kDa Ro(SSA) ELISA detects autoantibodies in Sjögren's syndrome sera that go undetected by conventional serologic assays.
|
9150073 |
1997 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, this hypothesis implies that the fundamental abnormality in SCLE and neonatal LE is the production of high levels of Ro/SS-A autoantibody; however, equally high levels of Ro/SS-A antibodies having similar molecular specificities are frequently encountered in other conditions such as Sjögren's syndrome in which LESSD is seen only infrequently.
|
8628749 |
1996 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
SS-A/Ro autoantibodies are detected in high frequency in patients with subacute cutaneous lupus, neonatal lupus, systemic lupus erythematosus, and Sjögren syndrome.
|
8823369 |
1996 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that Greek patients had less inflammatory articular disease, fewer extra-articular manifestations, less radiological joint destruction, and a high frequency of Ro(SSA) antibodies linked to a higher prevalence of secondary SS.
|
8846545 |
1996 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome.
|
8596150 |
1995 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA association of anti-Ro60 and anti-Ro52 antibodies in Sjögren's syndrome.
|
7530962 |
1994 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjögren's syndrome and systemic lupus erythematosus.
|
7964985 |
1994 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients suffering from systemic lupus erythematosus (SLE) or Sjögren's syndrome (SS) often contain autoantibodies directed to the Ro(SS-A) complex.
|
7693382 |
1993 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRw52 is closely related to annular erythema in anti-Ro(SS-A)-positive Japanese patients with Sjögren's syndrome.
|
8432914 |
1993 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro/SS-A autoantibodies are frequently associated with subacute cutaneous lupus erythematosus, neonatal lupus erythematosus and Sjögren's syndrome.
|
8509157 |
1993 |