|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This, on the one hand, characterized two autoantigen-targeting microRNAs in Sjögren's syndrome and, on the other hand, suggested that downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjögren's syndrome.
|
26888739 |
2016 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome.
|
8596150 |
1995 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.
|
27460476 |
2016 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjögren's syndrome and systemic lupus erythematosus.
|
7964985 |
1994 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus.
|
9125110 |
1997 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro52/Trim21 is targeted as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome.
|
19635858 |
2009 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although primary and secondary SS were most strongly associated with this DS specificity (MT2), the anti-Ro (SS-A) and anti-La (SS-B) antibody responses were more closely allied to DR antigens.
|
6208913 |
1984 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13-24 residues long, of Ro52/Ro60 proteins.
|
16356190 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that ACA/SS-A double positive SS is distinct from ACA single positive and SSA single positive SS.
|
29251022 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies binding the Ro (or SSA) and La (or SBB) proteins are commonly found in a high proportion of sera from patients with systemic lupus erythematosus or Sjögren's syndrome.
|
12410797 |
2002 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lupus-like manifestations consisted of pericarditis, pleuritis, and positive antinuclear and anti-SSA (Sjögren-syndrome A) antibodies.
|
26216333 |
2015 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The three mothers were found to suffer from Sjögren's syndrome; they all tested positive for anti-SSA and SSB antibodies and had lymphocyte infiltration into the small salivary gland.
|
1607484 |
1992 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between HLA and SS was restricted to patients with anti-SSA and/or anti-SSB; no association with HLA was observed in patients in group 1 (no antibody).
|
12905478 |
2003 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome.
|
17552056 |
2007 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.
|
15916807 |
2006 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Traditional biomarkers for SS include the autoantibodies anti-Sjögren's syndrome-related antigen A (SS-A/Ro), anti-Sjögren's syndrome-related antigen B (SS-B/La), antinuclear antibody (ANA) titers, and rheumatoid factor (RF).
|
28283891 |
2017 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SSA(Ro) antibodies were detected in 48% while seronegative patients were diagnosed with Sjögren's syndrome based on sialadenitis on minor salivary gland biopsy with a focus score ≥1.
|
31354737 |
2019 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings may indicate a role for apoptosis in the induction and facilitation of humoral responses to Ro52, Ro60 and La48 in the autoimmune exocrinopathy of SS.
|
12410795 |
2002 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because the SS-A/Ro and SS-B/La autoantibody responses in SS and systemic lupus erythematosus (SLE) show even stronger correlations with HLA alleles, HLA-DR and DQ alleles were examined using restriction fragment length polymorphisms (RFLP) in white and black patients with SS and/or SS having anti-Ro and anti-La antibodies.
|
2571337 |
1989 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production.
|
12646630 |
2003 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that Greek patients had less inflammatory articular disease, fewer extra-articular manifestations, less radiological joint destruction, and a high frequency of Ro(SSA) antibodies linked to a higher prevalence of secondary SS.
|
8846545 |
1996 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren's syndrome: data from a nationwide cohort for Sjögren's syndrome in Korea.
|
31376264 |
2019 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A number of systemic features have also been described and the presence of autoantibodies against the ubiquitously expressed ribonucleoprotein particles Ro (Sjögren's-syndrome-related antigen A - SSA) and La (SSB) further underline the systemic nature of Sjögren's syndrome.
|
21777618 |
2011 |
|
Sjogren's Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS.
|
29242559 |
2017 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
As TAP2*Bky2 had a strong linkage disequilibrium with DRB1*08032, TAP2*Bky2 or its haplotype with DRB1*08032 may be involved in SS-A/Ro antibody production not only in SS but also SLE patients, indicating that TAP2*Bky2 may be a susceptible gene not only to the disease of SS but also to the SS-A/Ro autoantibody production.
|
12729048 |
2003 |