|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.
|
9400936 |
1997 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BRCA2 protein expression in sporadic breast carcinoma with or without allelic loss of BRCA2.
|
10797254 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to evaluate the level of expression of the BRCA1 and BRCA2 proteins in sporadic breast cancer cases to determine the functional role of these genes in breast carcinogenesis.
|
25879355 |
2016 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA2-associated breast cancer is more sensitive to standard first-line chemotherapy for metastatic breast cancer in comparison with sporadic breast cancer, especially to anthracyclines.
|
19564533 |
2009 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, this study reports for the first time CAV1 expression in BRCA1 and BRCA2 hereditary breast cancer and identifies CAV1 as a marker associated with a basal-like-phenotype in both hereditary and sporadic breast cancer.
|
16541313 |
2006 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently demonstrated that the progression of breast cancer in female carriers of a germline BRCA1 or BRCA2 mutation follows specific genetic pathways, distinct from each other and from sporadic breast cancer.
|
9892109 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of BRCA2 correlates with reduced long-term survival of sporadic breast cancer patients.
|
15015609 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For BC, BRCA carriers showed a more advanced histological stage, higher risk of bilateral neoplasms (OR = 4.3; 95% CI = 1.3-11.4, for BRCA2 carriers) and worse OS rate at 5-, 10- and 15- years, than women with sporadic tumors.
|
31771539 |
2019 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whereas the cumulative 10-year incidence of second primary breast cancer is high in BRCA1 mutation carriers, the estimates in BRCA2 mutation carriers and women with variants of unknown clinical significance are similar to those reported in women with sporadic breast cancer.
|
25975955 |
2015 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate LOH of BRCA1 (17q21) and BRCA2 (13-q12-13) in sporadic breast cancer, polymerase chain reaction (PCR)-based fluorescent DNA technology for detection of microsatellite polymorphisms was applied.
|
8630282 |
1996 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine if there is any difference in PML protein expression in breast cancer of BRCA1 and BRCA2 gene mutation carriers compared to sporadic breast cancer and if the PML protein can be used as a prognostic marker.
|
17822314 |
2007 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of BRCA1 and BRCA2 from 793 Korean patients with sporadic breast cancer.
|
17100994 |
2006 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this exploratory analysis, we found little indication that common variation in BRCA2 dramatically impacts sporadic breast cancer risk.
|
15317758 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, EMSY amplification occurred at a lower frequency in BRCA2 mutation carriers providing evidence to support EMSY amplification as a somatic surrogate for BRCA2 loss in sporadic breast cancer.
|
19636701 |
2010 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The studies we have performed during the last few years in familial breast tumours (BRCA1, BRCA2 and non-BRCA1/2) widen questions about the development of sporadic breast cancer to hereditary breast cancer.
|
18596026 |
2008 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with hereditary breast cancer due to BRCA2 have a similar prognosis when compared with age-matched sporadic breast cancer patients.
|
10550133 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The prognostic significance of BRCA2 mRNA levels in tumor tissues was studied in sporadic breast cancer patients.
|
11948466 |
2002 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were tested for LOH on chromosome band 13q12-q14, using 11 highly polymorphic microsatellite markers.
|
7577475 |
1995 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allelic loss at the BRCA1, BRCA2 and TP53 loci in human sporadic breast carcinoma.
|
10704738 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To obtain better a molecular characterization of BRCA2 expression in sporadic breast cancer, we quantified BRCA2 mRNA by means of RT - PCR in a large series of human primary breast tumours.
|
10498873 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism.
|
17945002 |
2007 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early-onset diagnosis is an eligibility criterion for BRCA1 and BRCA2 (BRCA) testing in sporadic breast cancer patients.
|
25342642 |
2014 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the current study was to investigate the frequency of these BRCA1 and BRCA2 mutations in southern Iranian familial and sporadic cases with breast cancer.Two hundred fifty women with sporadic breast cancer, 55 women with a familial history of breast cancer in their first degree-relatives and 200 healthy women formed the studied groups.
|
19877752 |
2009 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast carcinoma.
|
9221812 |
1997 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The BRCAx-related tumors were characterized by more frequent LOH at 22q relative to sporadic breast cancer (P < 0.02), and differed significantly from BRCA1- and BRCA2-related tumors in their positivity for Bcl2.
|
16551851 |
2006 |