|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were tested for LOH on chromosome band 13q12-q14, using 11 highly polymorphic microsatellite markers.
|
7577475 |
1995 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that BRCA2 and RB1 may be both distinct target loci for AI on chromosome 13 in sporadic breast cancer.
|
8616837 |
1996 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate LOH of BRCA1 (17q21) and BRCA2 (13-q12-13) in sporadic breast cancer, polymerase chain reaction (PCR)-based fluorescent DNA technology for detection of microsatellite polymorphisms was applied.
|
8630282 |
1996 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast carcinoma.
|
9221812 |
1997 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.
|
9400936 |
1997 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hereditary breast cancer has been associated with mutations in the BRCA1 and BRCA2 genes and has a natural history different from sporadic breast cancer.
|
9652611 |
1998 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA2 functions as a tumour-suppressor gene in about 35% of large familial breast-cancer clusters; its role in the pathogenesis of sporadic breast cancer is less clear.
|
9724085 |
1998 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently demonstrated that the progression of breast cancer in female carriers of a germline BRCA1 or BRCA2 mutation follows specific genetic pathways, distinct from each other and from sporadic breast cancer.
|
9892109 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, it is still undetermined whether BRCA1 and BRCA2 play similar important roles in sporadic breast cancer.
|
10369075 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To obtain better a molecular characterization of BRCA2 expression in sporadic breast cancer, we quantified BRCA2 mRNA by means of RT - PCR in a large series of human primary breast tumours.
|
10498873 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with hereditary breast cancer due to BRCA2 have a similar prognosis when compared with age-matched sporadic breast cancer patients.
|
10550133 |
1999 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allelic loss at the BRCA1, BRCA2 and TP53 loci in human sporadic breast carcinoma.
|
10704738 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BRCA2 protein expression in sporadic breast carcinoma with or without allelic loss of BRCA2.
|
10797254 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.
|
10819531 |
1998 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer.
|
11004669 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No definite conclusion can be made with regard to the prognosis of BRCA2-associated breast cancer, but large differences in comparison with sporadic breast cancer are not likely to exist.
|
11060339 |
2000 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed 27 Greek patients with familial breast cancer the majority of those having one first and one second degree relatives affected and 28 patients with sporadic breast cancer for BRCA2 germline mutations.
|
11754111 |
2002 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The prognostic significance of BRCA2 mRNA levels in tumor tissues was studied in sporadic breast cancer patients.
|
11948466 |
2002 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of BRCA2 correlates with reduced long-term survival of sporadic breast cancer patients.
|
15015609 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this exploratory analysis, we found little indication that common variation in BRCA2 dramatically impacts sporadic breast cancer risk.
|
15317758 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome.
|
15355907 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The total prevalence of germline pathogenic mutations in BRCA1 and/or BRCA2 in Korean sporadic breast cancer is estimated to be about 3.1%.
|
15365993 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that the imaging findings of BRCA1 and BRCA2-associated carcinomas differ from each other and from age-matched cases of sporadic breast carcinoma.
|
15451348 |
2004 |
|
Sporadic Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the X inactivation pattern in patients with familial non-BRCA1/BRCA2 breast cancer (n = 272), BRCA1/BRCA2 germline mutations (n = 35), and sporadic breast cancer (n = 292).
|
15879497 |
2005 |
|
Sporadic Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, this study reports for the first time CAV1 expression in BRCA1 and BRCA2 hereditary breast cancer and identifies CAV1 as a marker associated with a basal-like-phenotype in both hereditary and sporadic breast cancer.
|
16541313 |
2006 |