Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Functionally, these tumor-educated monocytes directly accelerated tumor invasion and metastasis through bursting various pro-tumor factors and activating signal transducer and activator of transcription 1/3, extracellular signal-regulated kinase 1/2, and v-akt murine thymoma viral oncogene homolog signaling in HCC cells.
|
30070719 |
2019 |
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
There was also coordinated down regulation of chemoattractant ligand/receptor pairs (CCL19/CCR7, CXCL9/CXCR3, IL15/IL15R), interferon regulated genes (STAT1, IRF-1,-4,-7, IFI-27,-35), granzyme/granulysin, MHC class I and immune proteasome (PSMB-8,-9,-10) expression in metastases.
|
30203045 |
2018 |
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Comparing the proteomic profiles of vSCC morphologic variants indicates that increased expression of collagen subunits and decreased expression of STAT1 are associated with a more aggressive tumor variant, defined by increased incidence of nodal metastases and tumor recurrence.
|
29225558 |
2017 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Importantly, we found anti-IL-17 treatment can rescue STAT1 deficient animals from developing exacerbated metastasis to the lungs which could be important for immunotherapies for immunocompromised breast cancer patients.
|
29147627 |
2017 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
CTD_human |
Importantly, we found anti-IL-17 treatment can rescue STAT1 deficient animals from developing exacerbated metastasis to the lungs which could be important for immunotherapies for immunocompromised breast cancer patients.
|
29147627 |
2017 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggested that OSM suppresses SLUG expression and tumor metastasis of LAC through inducing the inhibitory effect of the STAT1-dependent pathway and suppressing the activating effect of STAT3-dependent signaling.
|
27486982 |
2016 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer.
|
25686822 |
2015 |
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
IFN stimulation enhanced the expression levels of P‑STAT1 in the renal cell carcinoma tissues, and enhancement of the P‑STAT1 expression levels was associated with tumor relapse and metastasis.
|
24626739 |
2014 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our results suggest that CUG2 enhances metastasis and drug resistance through STAT1 activation, which eventually contributes to tumor progression.
|
23917355 |
2013 |
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Whole genome transcriptional analysis clearly indicate that regression of melanoma metastases is due to an acute immune rejection mediated by the upregulation of genes involved in antigen presentation and interferon mediated response (STAT-1/IRF-1) in all the regressing metastases from both patients.
|
21964766 |
2012 |