STAT1, signal transducer and activator of transcription 1, 6772
N. diseases: 531; N. variants: 41
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.040 | Biomarker | disease | BEFREE | During infection with respiratory syncytial virus (RSV), STAT1-deficient mice had reduced numbers of antiviral IFN-γ<sup>+</sup> ILC1 and increased numbers of immunopathologic IL-5<sup>+</sup> and IL-13<sup>+</sup> ILC2 and IL-17A<sup>+</sup> ILC3 compared with RSV-infected wild-type mice. | 28576981 | 2017 |
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0.040 | GeneticVariation | disease | BEFREE | Hence, we provide mechanistic insight that the FokI VDR polymorphism renders STAT1-mediated antiviral immune reactions to RSV infection non-responsive to vitamin D control, resulting in enhanced immunopathology and exacerbated RSV bronchiolitis. | 24105653 | 2014 |
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0.040 | Biomarker | disease | BEFREE | STAT1(-/-) mice are more susceptible to RSV replication and disease than wild-type mice. | 18788941 | 2008 |
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0.040 | Biomarker | disease | BEFREE | Moreover, differences in gene expression profiles were found in genes involved in the immune response against respiratory syncytial virus, such as those encoding signal transducer and activator of transcription 1 and an inflammatory mediator showing enhanced production in asthma (prostaglandin E(2) receptor 2). | 18614563 | 2008 |