Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
This, as well as the feedback role of SOCS3 in STAT3 pathway and NFƙB-p50 expression, may indicate that the placenta has a role in protecting the fetus from damage due to inflammatory response, which is common in diabetes.
|
31848914 |
2020 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the role of the signal transducer and activator of transcription 3 (STAT3) pathway in diabetes-induced immune cell activation and its contribution to retinal microvascular degeneration.
|
31286987 |
2019 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Pretreatment with the antioxidant N-acetylcysteine (NAC) attenuated hyperglycemia-induced reduction of Cav-3 expression and Akt and STAT3 activation and restored RPC-mediated cardioprotection in diabetes, which was abolished by cardiac-specific knockdown of Cav-3 by AAV9-shRNA-Cav-3, PI3K/Akt inhibitor wortmannin, or JAK2/STAT3 inhibitor AG490, respectively.
|
31583053 |
2019 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
However, the effect of diabetes on the phosphorylation or activation of cardiac STAT3 appears to be controversial.
|
31616516 |
2019 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway has been demonstrated to be involved in diabetes‑associated cardiovascular complications.
|
29484371 |
2018 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
These findings suggest that STAT3 inhibition promotes cellular reprogramming into β-like cells, orchestrated by defined transcription factors, which may lead to the establishment of cell therapies for curing diabetes.
|
30266298 |
2018 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
STAT3 in cardiac fibrosis of diabetes is induced by high glucose through promotion of the STAT3‑associated signaling pathway.
|
29115516 |
2018 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Moreover, forced expression of forkhead box protein O1 (FoxO1), an antagonist for activated Stat3, specifically in β-cells ameliorated β-cell EMT and β-cell loss and prevented the onset of diabetes in mice undergoing PDL.
|
28775125 |
2017 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
SD rats administered leptin immunogen also showed glucose intolerance, β- cell reduction in the pancreas, and deregulation of JAK2-STAT3/PI3K signaling, indicating that Lep rats were at risk of diabetes.
|
28242305 |
2017 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
STAT3 is over-expressed in endometrial cancer, and diabetes is a risk factor for the development of type 1 endometrial cancer.
|
28114390 |
2017 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
Collectively, we demonstrate that obesity-associated inflammation and metabolic disturbances depend on interleukin-6/Stat3-dependent formation of a distinct NK population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes.
|
28683285 |
2017 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
These findings suggest that controlling blood glucose or using a STAT3 inhibitor as an alternative approach may improve the therapeutic outcome of CCA patients with DM.
|
26743134 |
2016 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes.
|
23747931 |
2013 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|