Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk.
|
30289982 |
2019 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that <i>STAT4/5B</i> mRNA expression levels in HCC tissues were lower than those in normal tissues.
|
31564902 |
2019 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, a genome-wide association study (GWAS)-identified polymorphism in the STAT4 gene that contributes to the risk for hepatocellular carcinoma (HCC) was shown to be associated with the full spectrum of hepatitis B virus (HBV) outcomes in Asian patients.
|
29963713 |
2018 |
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
To sum up, our study suggests that <i>STAT4-</i>rs7574865 is a risk factor for HCC.
|
30310516 |
2018 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the included studies revealed that STAT4 rs7574865 polymorphism contributed to the risk of HCC under all four genetic models, consisting of the allelic model (G vs. T: odds ratio [OR], 1.25; 95% confidence interval [CI], 1.19-1.30), the dominant effect model (GG + GT vs. TT: OR, 1.52; 95% CI, 1.26-1.84), the recessive effect model (GG vs. GT + TT: OR, 1.35; 95% CI, 1.21-1.50), and the co-dominant effect model (GG vs.. TT: OR, 1.72; 95% CI, 1.42-2.10) comparisons.
|
27126090 |
2017 |
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Meanwhile, polymorphisms in KIF1B, GRIK1, and STAT4 were associated with HBV-related hepatocellular carcinoma (HCC).
|
26255971 |
2016 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In the gene expression analyses, although no significant differences in mRNA expression of nearby genes according to genotypes were detected, a significantly decreased mRNA expression in HCC subjects was observed in STAT4, HLA-DQA1, and HLA-DQB1.
|
25913043 |
2015 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
STAT4 protein expression was significantly lower in HCC tissues than in normal liver tissues.
|
25852285 |
2015 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population.
|
26745093 |
2015 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
STAT4 gene polymorphism and risk of chronic hepatitis B-induced hepatocellular carcinoma.
|
25178516 |
2015 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study.
|
25665738 |
2015 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC).
|
25798064 |
2015 |
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious.
|
25365208 |
2014 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Low STAT4 expression (P = 0.030) and presence of portal venous invasion or hepatic venous invasion (P = 0.006) were independent risk factors for HCC recurrence.
|
24965572 |
2014 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).
|
23242368 |
2013 |
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).
|
23242368 |
2013 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our study highlights the reported variant to be a trivial factor and possibly other confounding factors may regulate STAT4 expression during HCC development.
|
23748017 |
2013 |
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).
|
23242368 |
2013 |
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).
|
23242368 |
2013 |