Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrated that IL7 mediates an intrinsic and physiologic mechanism of GC resistance in normal thymocyte development that is retained during leukemogenesis in a subset of T-ALLs and is reversible with targeted inhibition of the IL7R/JAK/STAT5/BCL-2 axis.
|
31687977 |
2020 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As mutations in STAT5B, but not STAT5A, have been frequently described in hematopoietic tumors, we used BCR/ABL as model systems to investigate the contribution of STAT5A or STAT5B for leukemogenesis.
|
30679796 |
2019 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show here that genetic and pharmacologic inhibition of STAT5 activity suppresses cell growth, induces apoptosis, and inhibits leukemogenesis of Ph+ cell lines and patient-derived newly diagnosed and relapsed/TKI-resistant Ph+ ALL cells <i>ex vivo</i> and in mouse models.
|
30154155 |
2018 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific miRNA silencing or the inhibition of Stat5-associated pathways might contribute to preventing the risk of leukemogenesis in G-CSFRIV(+) HSPCs.
|
25730818 |
2015 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results reveal a leukemic pathway involving FAK/Tiam1/Rac1/PAK1 and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 in leukemogenesis.
|
25456130 |
2014 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results point out to a hitherto undescribed link between STAT5 and oxidative stress and provide new insights into STAT5 functions and their roles in leukemogenesis.
|
22522791 |
2012 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To elucidate the biochemical networks connecting the Kit mutant to leukemogenesis, in the present study, we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven murine leukemia proerythroblasts and identified Shp2 and Stat5 as proximal effectors of Kit.
|
22438255 |
2012 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, the essential role of STAT3 activation as well as STAT 5 activation in nucleophosmin-ALK fusion protein-mediated lymphomagenesis was reported.
|
18755494 |
2009 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One possible pathomechanism causing leukemia is that clones of cells harboring acquired CSF3R mutations have a growth advantage over wild type cells in vivo during granulocyte-colony stimulating factor treatment due to activation of STAT5 and ss-catenin, both known to be involved in leukemogenesis.
|
18536571 |
2008 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies conducted with constitutively active Stat5 mutants (Stat51*6 and cS5F) have shown that deregulated Stat5 activity promotes leukemogenesis.
|
17038539 |
2007 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Myeloid leukemogenesis is a multi-stage process that can involve constitutively activated receptors and downstream pathways involving STAT5, HOX genes, and HLF.
|
17379095 |
2007 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis.
|
16532027 |
2006 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data add to our understanding of the roles of G-CSF and Stat5 in normal granulopoiesis and leukemogenesis.
|
16111533 |
2005 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that Stat5 tetramers are associated with leukemogenesis.
|
15652752 |
2005 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, STAT5b-RARalpha and other APL fusion proteins may contribute to leukemogenesis by interaction with the STAT3 oncogene pathway.
|
11929748 |
2002 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, our data indicate that NPM/ALK-induced activation of STAT5 may play an important role in NPM/ALK-mediated lymphomagenesis.
|
11522649 |
2001 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, constitutive activation of STAT5 has been reported in patients' leukemic cells and is implicated in leukemogenesis.
|
10729993 |
2000 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, Flt3-ITD mutations induce factor-independent growth and leukemogenesis of 32D cells that are mediated by the Ras and STAT5 pathways.(Blood.2000;96:3907-3914)
|
11090077 |
2000 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, constitutively activated Stat1, Stat3, and Stat5 were identified in nuclear extracts of acute myeloid leukemia (AML) patients, suggesting involvement of constitutive Stat activity in the events of leukemogenesis.
|
9694725 |
1998 |