|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate that STK15/BTAK mRNA is over-expressed in the majority of breast cancers and its over-expression is significantly associated with CIN, implicating STK15/BTAK in carcinogenesis through induction of CIN.
|
11291073 |
2001 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we investigated the correlation of STK15/BTAK mRNA expression with CIN and various clinicopathological factors in human breast cancer.
|
11291073 |
2001 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate that STK15/BTAK mRNA is over-expressed in the majority of breast cancers and its over-expression is significantly associated with CIN, implicating STK15/BTAK in carcinogenesis through induction of CIN.
|
11291073 |
2001 |
|
Mammary Neoplasms, Experimental
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
|
12124350 |
2002 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated expression of STK15 was strongly associated with parameters of clinical aggressiveness including high histologic grade (P<.001), invasion (P<.001), increased rate of metastasis (P<.001), and decreased metastasis-free (P<.001) and overall (P<.001) survival of patients with bladder cancer.
|
12208897 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors with low levels of STK15 amplification (3-4 copies) showed minimal deviation in their chromosome copy number and diploid or near-diploid total nuclear DNA content.
|
12208897 |
2002 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated expression of STK15 was strongly associated with parameters of clinical aggressiveness including high histologic grade (P<.001), invasion (P<.001), increased rate of metastasis (P<.001), and decreased metastasis-free (P<.001) and overall (P<.001) survival of patients with bladder cancer.
|
12208897 |
2002 |
|
Carcinoma of bladder
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
STK15 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with aneuploidy and aggressive clinical behavior in human bladder cancer.
|
12208897 |
2002 |
|
Malignant neoplasm of urinary bladder
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Because clinical prognosis and tumor aneuploidy are tightly linked in human bladder cancer, we examined whether increased STK15 copy number and protein levels are linked to aneuploidy in bladder cancers.
|
12208897 |
2002 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
STK15 protein was visualized by immunohistochemistry in 205 formalin-fixed, paraffin-embedded human bladder tumors.
|
12208897 |
2002 |
|
ovarian neoplasm
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We examined copy-number changes with respect to six candidate genes, E2F1 (20q11.2), TGIF2 (20q11.2), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and BTAK (20q13), and then measured transcription levels of each candidate in 18 OC cell lines.
|
12417041 |
2002 |
|
Carcinoma, Ovarian Epithelial
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We examined copy-number changes with respect to six candidate genes, E2F1 (20q11.2), TGIF2 (20q11.2), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and BTAK (20q13), and then measured transcription levels of each candidate in 18 OC cell lines.
|
12417041 |
2002 |
|
Malignant neoplasm of ovary
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We examined copy-number changes with respect to six candidate genes, E2F1 (20q11.2), TGIF2 (20q11.2), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and BTAK (20q13), and then measured transcription levels of each candidate in 18 OC cell lines.
|
12417041 |
2002 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases.
|
12460888 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor.
|
12460888 |
2002 |
|
Secondary Neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases.
|
12460888 |
2002 |
|
Adult Liver Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This HCC marker set contained several cancer-related genes, including serine/threonine kinase 15 (STK15), which has been implicated in chromosome segregation abnormalities but which has not been linked previously with liver cancer.
|
12591738 |
2003 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This HCC marker set contained several cancer-related genes, including serine/threonine kinase 15 (STK15), which has been implicated in chromosome segregation abnormalities but which has not been linked previously with liver cancer.
|
12591738 |
2003 |
|
Malignant neoplasm of liver
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This HCC marker set contained several cancer-related genes, including serine/threonine kinase 15 (STK15), which has been implicated in chromosome segregation abnormalities but which has not been linked previously with liver cancer.
|
12591738 |
2003 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The extent of STK15 expression was not significantly correlated with the size, degree of differentiation, and metastasis status of the tumors.
|
12631597 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
STK15 protein expression was also examined in normal pancreatic tissues and tumors by Western blotting and immunohistochemistry.
|
12631597 |
2003 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results show that STK15 is overexpressed in pancreatic tumors and carcinoma cell lines and suggest that overexpression of STK15 may play a role in pancreatic carcinogenesis.
|
12631597 |
2003 |
|
Pancreatic carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer.
|
12631597 |
2003 |
|
Malignant neoplasm of pancreas
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer.
|
12631597 |
2003 |
|
ovarian neoplasm
|
0.090 |
Biomarker
|
disease |
LHGDN |
To our knowledge, this is the first demonstration of recurrent activation and overexpression of BTAK/Aurora-A in human ovarian cancer, which may play a critical role in development of this malignancy.
|
12684414 |
2003 |