AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1832661
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
ANOPHTHALMIA AND PULMONARY HYPOPLASIA 		0.010 Biomarker disease BEFREE The combination also reduces the growth of PDAC xenografts <i>in vivo</i> Mechanistically, it was found that inhibiting methyltransferases of the H3K9 pathway in cells, which are arrested in G<sub>2</sub>-M after targeting AURKA, decreases H3K9 methylation at centromeres, induces mitotic aberrations, triggers an aberrant mitotic check point response, and ultimately leads to mitotic catastrophe. 28442587 2017