STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Disease: Familial (FPAH) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.030 GeneticVariation disease BEFREE Despite the fact that Peutz-Jeghers syndrome is usually an early onset disease with characteristic clinical features, predictive and diagnostic testing for LKB1 mutations will be useful for selected patients in both familial and non-familial contexts. 10353780 1999
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.030 Biomarker disease BEFREE Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. 9887330 1999
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.030 Biomarker disease BEFREE Our results demonstrate that germline and somatic genetic alterations of the STK11/LKB1 gene may play a causal role in carcinogenesis and that the same gene contributes to the development of both sporadic and familial forms of cancer. 10362809 1999