|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidemiological data suggest that infections by STEC strains that produce only Stx2a progress more often to a life-threatening sequela of infection called hemolytic-uremic syndrome (HUS) than isolates that make Stx1a only or produce both Stx1a and Stx2a.In this study, we found that an <i>E. coli</i> O26:H11 strain that produces both Stx1a and Stx2a was virulent in streptomycin- and ciprofloxacin-treated mice and that mice were protected by administration of an anti-Stx2 antibody.
|
30670557 |
2019 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the various Stx subtypes, Stx1a and Stx2a are of eminent clinical importance in human infections being associated with life-threatening hemorrhagic colitis and hemolytic uremic syndrome, whereas Stx2e subtype is associated with porcine edema disease with a generalized fatal outcome for the animals.
|
29939014 |
2018 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidemiological evidence suggests that Stx2-producing E. coli strains are more frequently associated with HUS than Stx1-producing strains.
|
26483409 |
2016 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cluster A-strains including the HUS-strain (n = 35) carried genes associated with severe disease in humans (stx2a, stx2d, ehxA, saa, subAB1, lpfAO113 , terE combined with stx1a, espP, iha).
|
24987616 |
2014 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The age of the patient (≤5 years) and the genes eae and stx2a were significantly associated with HUS-associated STEC (P < 0.05 for each parameter), while stx1 was associated with non-HUS-associated STEC (P < 0.05).
|
24920783 |
2014 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bacterial Shiga-like toxins (Stx1, Stx2) are primarily responsible for HUS and the kidney and neurologic damage that ensue.
|
23402998 |
2013 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
None of the infected children developed haemolytic uraemic syndrome (HUS) or other complications of STEC. stx1 was present in 83 % of strains, stx2 in 17 %, eae in 72 %, ehxA in 59 % and astA in 14 %.
|
21292859 |
2011 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Non-O157 isolates with at least stx2 were not more likely to cause severe illness (bloody diarrhea, hospitalization, or HUS) than were non-O157 isolates with only stx1.
|
19548834 |
2009 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Severe disease in the form of bloody diarrhea and the hemolytic uremic syndrome is attributable to Shiga toxin (Stx), which exists as 2 major types, Stx1 and Stx2.
|
17085726 |
2007 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of stx(2) both alone and in combination with stx(1) was significantly (chi(2)=23.16, P<0.00001, CI(95) [2.29; 9.76]) associated with HUS.
|
17157559 |
2007 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Virulence gene profiles were as follows: 61% stx(1) but not stx(2); 22% stx(2) but not stx(1); 17% both stx(1) and stx(2); 84% intimin (eae); and 86% enterohemolysin (E-hly). stx(2) was strongly associated with an increased risk of HUS, and eae was strongly associated with an increased risk of bloody diarrhea.
|
16170761 |
2005 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Shiga toxin 1 (Stx-1) and Stx-2 produced by enterohemorrhagic Escherichia coli cause the diarrhea-associated hemolytic uremic syndrome (HUS).
|
16131569 |
2005 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, mitomycin C treatment had a minimal effect on Stx1 production by both HUS- and bovine-associated STEC.
|
12571029 |
2003 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These associations were not affected by the stx genotype. stx1(-)/stx2(+) E. coli O157:H7 strains were more commonly associated with HUS than were stx1(+)/stx2(+) strains (P=.21), and 1 child with HUS was infected with a rare stx1(+)/stx2(-) isolate.
|
11807695 |
2002 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objectives of this study were to: 1). confirm whether there exists a relationship between severity and clinical presentation of HUS; 2). prove the existence of Stx1 and/or Stx2 in the faeces of HUS patients; and 3). detect the presence of Stx1- and/or Stx2-producing E. coli.
|
10816611 |
1999 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All human O157 strains that were associated with sporadic cases of hemolytic-uremic syndrome (HUS) carried both the stx1 and stx2 toxin-encoding genes and were eaeA positive.
|
9986852 |
1999 |
|
Hemolytic-Uremic Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, glomerular pathology in HUS may also result from a direct effect of Stx1 on mesangial cells.
|
9767527 |
1998 |