SYN2, synapsin II, 6854

N. diseases: 73; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease BEFREE A reduction of the phosphoprotein synapsin II has also been implicated in schizophrenia and has a well-known role in the maintenance of the presynaptic reserve pool and vesicle mobilization. 30582667 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease BEFREE The associations of SYN II are identified in various studies that are linked to the onset of Schizophrenia. 29436999 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease BEFREE Synapsin II, in particular, has been implied as a candidate gene for schizophrenia. 23529008 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease BEFREE The rs2289708 SNP (SYN2) did not show any association between schizophrenia and controls. 22807112 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease BEFREE Polymorphisms of the SYNAPTOGYRIN1 (SYNGR1) and SYNASINII (SYNII) genes have been shown to be a risk factor for bipolar disorder or schizophrenia. 19665806 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease BEFREE Haplotype analysis using markers in introns 5 and 6 of Syn2 provided a single haplotype that is significantly associated with schizophrenia using TRANSMIT (nominal p<0.00000001) and PDTPHASE (nominal p=0.02). 17766091 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease LHGDN Haplotype analysis using markers in introns 5 and 6 of Syn2 provided a single haplotype that is significantly associated with schizophrenia using TRANSMIT (nominal p<0.00000001) and PDTPHASE (nominal p=0.02). 17766091 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease LHGDN This confirms our previous study and provides further support for the role of synapsin II variants in susceptibility to schizophrenia. 15449241 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 GeneticVariation disease BEFREE This confirms our previous study and provides further support for the role of synapsin II variants in susceptibility to schizophrenia. 15449241 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease BEFREE This study suggests a positive association between synapsin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia. 15271586 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease LHGDN This study suggests a positive association between synapsin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia. 15271586 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease BEFREE Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. 11086983 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease HPO
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.490 Biomarker disease CTD_human
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease BEFREE These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. 27515700 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 AlteredExpression disease BEFREE Synapsin II gene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder: effect of lifetime intake of antipsychotic drugs. 23529008 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. 19665806 2009
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.310 AlteredExpression phenotype BEFREE We are the first to discover that in STZ-induced diabetic rats the activation of mTOR mediates the upregulation of synapsin II and neurite outgrowth, both contributing to hyperalgesia. 30785256 2019
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.310 GeneticVariation phenotype BEFREE Synapsin II (SynII) deletion produces epileptic seizures and overexcitability in neuronal networks. 30858140 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.310 Biomarker phenotype CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.310 Biomarker phenotype CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008
CUI: C0022333
Disease: Jacksonian Seizure
Jacksonian Seizure 		0.300 Biomarker disease CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008
CUI: C0036572
Disease: Seizures
Seizures 		0.300 Biomarker phenotype CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.300 Biomarker disease CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.300 Biomarker disease CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217 2008