SYP, synaptophysin, 6855

N. diseases: 243; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3275408
Disease: MENTAL RETARDATION, X-LINKED 96
MENTAL RETARDATION, X-LINKED 96 		0.700 Biomarker disease GENOMICS_ENGLAND A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. 19377476 2009
CUI: C3275408
Disease: MENTAL RETARDATION, X-LINKED 96
MENTAL RETARDATION, X-LINKED 96 		0.700 GeneticVariation disease UNIPROT A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. 19377476 2009
CUI: C3275408
Disease: MENTAL RETARDATION, X-LINKED 96
MENTAL RETARDATION, X-LINKED 96 		0.700 Biomarker disease CTD_human
CUI: C3275408
Disease: MENTAL RETARDATION, X-LINKED 96
MENTAL RETARDATION, X-LINKED 96 		0.700 CausalMutation disease CLINVAR
CUI: C1136249
Disease: Mental Retardation, X-Linked
Mental Retardation, X-Linked 		0.500 Biomarker disease CTD_human The screen has discovered nine genes implicated in XLMR, including SYP, ZNF711 and CASK reported here, confirming the power of this strategy. 19377476 2009
CUI: C1136249
Disease: Mental Retardation, X-Linked
Mental Retardation, X-Linked 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 Biomarker disease BEFREE Our findings of moderate-large reductions in synaptophysin in hippocampus and frontal cortical regions, and a tendency for reductions in other pre- and postsynaptic proteins in the hippocampus are consistent with models that implicate synaptic loss in schizophrenia. 29511299 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 AlteredExpression disease BEFREE We found consistent evidence of morphological alterations of dendrites of glutamatergic neurons in the cerebral cortex of subjects with schizophrenia and of reduced levels of the axon bouton marker synaptophysin. 25315318 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE We searched for genetic variants in the promoter region, all exons, and both UTR ends of the SYP gene using direct sequencing in a sample of patients with schizophrenia (n=586) and non-psychotic controls (n=576), both being Han Chinese from Taiwan, and conducted an association and functional study. 22348818 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 Biomarker disease LHGDN The levels and distribution of GAP-43 and synaptophysin proteins were measured in the dentate gyrus of subjects with schizophrenia and sex-, age-, and postmortem interval-matched normal controls and subjects with bipolar disorder. 15694236 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 Biomarker disease CTD_human In schizophrenia, synaptophysin mRNA was decreased, as was complexin II and its mRNA. 11483314 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 AlteredExpression disease BEFREE Synaptophysin expression is decreased in some cortical areas in schizophrenia. 10755070 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 AlteredExpression disease BEFREE These alterations in tissue levels of synaptophysin and SNAP-25 are consistent with the idea that the clinically observed 'hypofrontality' of schizophrenia arises from abnormalities of synaptic number or structural integrity in prefrontal cortex. 10089007 1999
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 AlteredExpression disease BEFREE A parallel study in rats showed no effect of haloperidol treatment upon hippocampal synaptophysin messenger RNA, suggesting that neuroleptic treatment does not underlie the reductions found in schizophrenia. 7477874 1995
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 Biomarker phenotype BEFREE A significant deficit of transforming growth factor-β1 (TGF-β1), paralleling memory deficits and depressive-like phenotype, was found in the hippocampus of Aβ-injected mice in combination with a significant reduction of the synaptic proteins synaptophysin and PSD-95. 31293421 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 Biomarker phenotype BEFREE Here, we tested the hypothesis that reactive astrocytes-mediated loss of synaptophysin (SYP) and CREB-regulated transcription coactivator 1 (CRTC1) contribute to dysfunction in glia gap junction communication and memory impairment after ischemic stroke. 31270712 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 Biomarker phenotype BEFREE Using an experimental model of brain iron accumulation, we have shown that iron induces severe memory deficits that are accompanied by oxidative stress, increased apoptotic markers, and decreased synaptophysin in the hippocampus of rats. 29374603 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 Biomarker phenotype BEFREE Taken together, our findings demonstrate that chronic NAC treatment alleviates acute LPS-induced working memory deficit through upregulating Cav-1 and SYP in mice. 29058042 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 AlteredExpression phenotype BEFREE Results from this study showed that DSP administration effectively ameliorated Aβ-induced learning and memory impairment in rats, markedly inhibited Aβ-induced hippocampal ROS production, effectively prevented Aβ-induced hippocampal neuronal damage and significantly restored hippocampal synaptophysin expression level. 28119081 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.350 Biomarker phenotype CTD_human Expression of VGLUTs contributes to degeneration and acquisition of learning and memory. 21295146 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.310 AlteredExpression phenotype BEFREE Moreover, the nanocomplexes significantly increased the level of synaptophysin and rescued memory loss of the AD transgenic mice without hematological or histological toxicity. 31193846 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.310 AlteredExpression disease BEFREE REST expression was restricted in non-small cell lung cancer (NSCLC) cells, and knockdown of REST could cause as much SYPT expression as in SCLC cells and weak CGA expression in NSCLC cells. 22449227 2012
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.310 Biomarker disease CTD_human Neuroendocrine differentiation as an indicator of chemosensitivity and prognosis in nonsmall cell lung cancer. 21595568 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.310 Biomarker phenotype CTD_human Expression of VGLUTs contributes to degeneration and acquisition of learning and memory. 21295146 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker disease BEFREE Furthermore, THS reduced mRNA expression of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β and increased synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus of AD mice. 31244052 2019