|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of synaptophysin for the diagnosis of BM metastasis in NB patients were (69%, 65.2%, 71.4%, 62.5%; respectively, P = .024).
|
31220430 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The aims of this study were to evaluate INSM1 expression in primary gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) and in their known metastases, in order to assess its sensitivity as compared with chromogranin-A (CgA) and synaptophysin (SYN), and to evaluate any change in expression between primary and metastatic disease.
|
31077609 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Four patients had a known history of breast cancer (remote in 3 and concurrent in 1), but the metastases (3 liver, 1 lung) labeled for chromogranin and/or synaptophysin, prompting misdiagnosis as neuroendocrine neoplasm.
|
30031098 |
2018 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Univariate analysis identified the clinical stage ≤ IIA (P = 0.042), tumor size ≤ 4 cm (P = 0.005), negative lymph nodes metastasis (P < 0.001), depth of stromal invasion ≤ 1/2 (P = 0.001), negative parametrial involvement (P = 0.004), and weak staining of synaptophysin (P = 0.037), and chromogranin (P = 0.011) as the prognostic factors for an improved overall survival, while chemotherapy and radiotherapy were not prognostic factors in the whole cohort.
|
28296773 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The pathology report revealed a large cell neuroendocrine carcinoma with numerous implants in perirectal adipose tissue and lymph metastasis in 2 lymph nodes (pT4aN1b), positive for synaptophysin, chromogranin and CD 56 with proliferation index Ki-67 50%.
|
27822951 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Surgical pathology confirmed the presence a recurrent carcinoid tumor in the EAC, with immunohistochemistry positive for pancytokeratin (MAK6), CD56, and synaptophysin, with chromogranin showing rare cells positive for cytoplasmic granules.There was no evidence of metastasis.
|
27749753 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The cells in the pleural fluid were immunopositive for synaptophysin, which was compatible with GCC, but p53 and ki67 staining indicated that the metastatic tumor was more aggressive.
|
25425263 |
2015 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Finally, we inspected human tissue specimens from skeletal metastases and detected prostate cancer cells positive for both IL-1β and synaptophysin while concurrently lacking prostate-specific antigen (PSA, KLK3) expression.
|
23536554 |
2013 |
|
Neoplasm Metastasis
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Here we describe a rare case of malignant neuroendocrine pancreatic tumor with multiple metastases in different organs showing strong positivity for synaptophysin, glucagon-like peptide 1, pan-cytokeratin, moderate positivity for chromogranin, Phe-5 and calcitonin and weak positivity for vasointestinal peptide.
|
9042254 |
1997 |