SYP, synaptophysin, 6855

N. diseases: 243; N. variants: 3
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE The protein α-synuclein, a major component of Lewy bodies in nigral neurons of aged and Parkinson's disease (PD) patients, normally co-localizes with synaptophysin and regulates the pool of synaptic vesicles. 30738909 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 AlteredExpression disease BEFREE Results showed that the level of postsynaptic density protein 95 was elevated in the brain of TMAS-treated PD model mice while the level of synaptophysin (SYP) did not show any change. 30993592 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 GeneticVariation disease BEFREE The Parkinson's disease-associated human mutant [A30P]alphaSYN was found to colocalize with betaSYN and synaptophysin in synapses of transgenic mouse brain. 10964942 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE Synaptophysin immunoreactivities were also similar in Parkinson's disease and control cases. 11044753 2000