TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Disease: Acidosis, Respiratory ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001127
Disease: Acidosis, Respiratory
Acidosis, Respiratory 		0.010 Biomarker phenotype BEFREE Chemogenetic [clozapine<i>-N-</i>oxide (CNO)-hM4Di] perturbation of <i>Tac1-Pet1</i> neuron activity blunted the ventilatory response of the respiratory CO<sub>2</sub> chemoreflex, which normally augments ventilation in response to hypercapnic acidosis to restore normal pH and PCO<sub>2</sub><i>Tac1-Pet1</i> axonal boutons were found localized to brainstem areas implicated in respiratory modulation, with highest density in motor regions. 28073937 2017