TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Disease: Adult Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.040 Biomarker disease BEFREE [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(1⁻11), [<sup>177</sup>Lu]DOTA-SP(4⁻11) and [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(5⁻11) radiobioconjugates bound specifically to NK-1 receptors expressed on glioblastoma cells with affinity in the nanomolar range. 30301182 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.040 AlteredExpression disease BEFREE The neuropeptide Substance P (SP) is the physiological ligand of the neurokinin-1 receptor, which is highly expressed in glioblastoma cells. 29611298 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.040 Biomarker disease BEFREE Tachykinin receptor neurokinin-1 (NK1R) is a promising target in glioblastoma therapy because of its overexpression in human glioblastoma. 28341744 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.040 Biomarker disease BEFREE Thus, in the present study, the effects of GBP and PGB on SP‑induced activation were investigated in the human glioblastoma astrocytoma U373 MG cell line, which expresses high levels of functional high‑affinity NK1R, and produces interleukin (IL)‑6 and IL‑8 in response to SP. 28849160 2017