|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression levels of miR-34b/c-5p and NK1R-Tr, but not NK1R-FL, were associated with enhanced malignant potential, such as tumour stage and Ki67 expression.
|
30334298 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, cytoplasmic expression of NK1R can be suggested as a potent prognostic factor as it has shown significant correlation with TNM and tumor grade.
|
30684188 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NK-1R antagonists exerted a dual effect in HB: Decreased both tumor volume and angiogenic activity.
|
31466222 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NK1R was upregulated in ESCC, and its overexpression correlated with larger tumour size, deeper tumour invasion, more perineural invasion and eventually caused poorer overall survival (OS).
|
31109645 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SP/NK1R system seems to play a role in tumor growth and development in endometrial cancer.
|
30225581 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The increased expression of NK1R-Tr might stimulate leiomyoma growth in a similar way to that observed in other steroid-dependent tumors.
|
27456549 |
2016 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SSTR1 hypermethylation in 64% of cases was correlated with tumor size (P = 0.037), stage (P = 0.037), SST methylation (P < 0.001), and expression of galanin (P = 0.03), GALR2 (P = 0.014), TAC1 (P = 0.023), and tachykinin receptor type 1 (TACR1) (P = 0.003).
|
25734919 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The substance P (SP)/NK-1 receptor (NK1R) complex represents an intriguing anticancer target for a variety of tumors, including hepatoblastoma (HB).
|
26516161 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No data exist on the presence of NK1R in osteosarcoma and whether this tumor responds to NK1R antagonists.
|
24190675 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this study was to define TAC1 and TACR1 methylation profiles for head and neck squamous cell carcinoma (HNSCC) tumors at diagnosis and follow-up and to evaluate their prognostic significance and value as a biomarker of recurrence.
|
23420374 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tr-NK-1R could prove useful as a diagnostic marker to identify patients at risk for neoplasia and may serve as a useful therapeutic target in the treatment of colitis-associated cancer.
|
21969570 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, after binding to NK-1 receptors, the NK-1 receptor antagonists specifically inhibit tumor cell proliferation (tumor cells die by apoptosis), angiogenesis and the migration of the tumor cells.
|
21034671 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cell biological studies were done with glioblastoma cell lines. neurokinin type-1 receptor (NK1R) autoradiography was done with 58 tumor biopsies.For labeling, (90)Y was mostly used.
|
16778112 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Enhanced NK-1R expression levels were not related to tumor grade but were associated with advanced tumor stage and poorer prognosis.
|
12746482 |
2003 |