TACR1, tachykinin receptor 1, 6869

N. diseases: 217; N. variants: 10
Disease: Septicemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 Biomarker disease BEFREE The genetic deletion of CSE led to decreased sepsis-induced SP and NK-1R in the liver, lungs and plasma SP suggesting H<sub>2</sub>S synthesized through CSE regulates the SP-NK-1R pathway in sepsis. 31261857 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 Biomarker disease BEFREE These data confirm the hypothesis that eliminating the SP/NK-1R interaction in a highly lethal murine model of sepsis leads to decreased morbidity and mortality through multiple mechanisms. 30095600 2019