|
Immunosuppression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The following characteristics were significantly associated with severe CKD: female gender (HR 1.34), older age (HR 1.38/10 year increment), catheter-related sepsis (HR 1.58), steroid maintenance immunosuppression (HR 1.50), graft failure (HR 1.76), ACR (HR 1.64), prolonged requirement for IV fluids (HR 2.12) or TPN (HR 1.94), and diabetes (HR 1.54).
|
28241392 |
2017 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aimed to determine whether tapasin is associated with chronic HBV (CHB) infection.
|
27510296 |
2016 |
|
Acute GVH disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hepatobiliary dysfunction was less frequent (12%) but carried a poor prognosis. aGVHD grade II-IV (OR 2.7, p = 0.02) and long-term TPN (OR 3.25, p = 0.01) increased the risk.
|
26518451 |
2016 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Consistent with published functional data showing that tapasin promotes antigen presentation, as well as tumor immune recognition and destruction by CD8(+) CTLs, a reduction in tapasin expression is associated with tumor progression in CRC.
|
26310568 |
2015 |
|
Pangastrointestinal system dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
(iii) Gastrointestinal failure and TPN dependency.
|
26081292 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer.
|
26310568 |
2015 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We suggest that analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for GBM patients, especially when considering immunotherapy.
|
25175688 |
2014 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed that the minor allele frequencies of TAPBP rs2071888 C>G (Thr260Arg) on exon 4 (P>0.05), which was in absolute linkage disequilibrium with rs1059288 T>C on 3'UTR, were significantly higher in the AERD group than in the aspirin-tolerant asthma group, and the P values remained significant after multiple comparisons (Pcorr=0.006, odds ratio: 1.37, 95% confidence interval: 1.11-1.69, additive model; Pcorr=0.009, odds ratio: 1.52, 95% confidence interval: 1.14-2.03, dominant model).
|
23736108 |
2013 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Modified CD8A or TAPBP gene function may contribute to the development of refractory CRS via altered MHC1 function and reduction of circulating CD8 lymphocytes.
|
23640800 |
2013 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Previous results from a genomewide association study of CRS were screened for polymorphisms in the CD8A, TAP1, TAP2, and TAPBP genes associated with MHC1 immunodeficiency syndrome.
|
23640800 |
2013 |
|
Aspirin exacerbated respiratory disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed that the minor allele frequencies of TAPBP rs2071888 C>G (Thr260Arg) on exon 4 (P>0.05), which was in absolute linkage disequilibrium with rs1059288 T>C on 3'UTR, were significantly higher in the AERD group than in the aspirin-tolerant asthma group, and the P values remained significant after multiple comparisons (Pcorr=0.006, odds ratio: 1.37, 95% confidence interval: 1.11-1.69, additive model; Pcorr=0.009, odds ratio: 1.52, 95% confidence interval: 1.14-2.03, dominant model).
|
23736108 |
2013 |
|
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MGUS progression correlated directly with calnexin, calreticulin, and tapasin and indirectly with delta, LMP2, and LMP10 expression levels; MM disease status did not correlate with APM levels.
|
20008301 |
2010 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules.
|
18316574 |
2008 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty-five single-nucleotide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for association with susceptibility to HPV16-associated cervical cancer.
|
18248301 |
2008 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty-five single-nucleotide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for association with susceptibility to HPV16-associated cervical cancer.
|
18248301 |
2008 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To test our hypothesis, a nonreplicating adenovirus vector encoding human Tpn (AdhTpn) was constructed to restore Tpn expression in vitro and in vivo in a murine lung carcinoma cell line (CMT.64) that is characterized by down-regulation of surface MHC class I due to deficiency in antigen-processing components.
|
18316574 |
2008 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty-five single-nucleotide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for association with susceptibility to HPV16-associated cervical cancer.
|
18248301 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
We selected five single nucleotide polymorphisms in genes with potential immune-related functions in the genomic regions of death-domain-associated protein 6 (DAXX, apoptosis associated), TAP-binding protein (TAPBP, human leukocyte antigen class I loading) and retinoic acid receptor beta (RXRB, vitamin D receptor function) that may bear relevance to the pathogenesis of T1D.
|
17389020 |
2007 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using reverse transcription PCR (RT-PCR), loss of heterozygosity (LOH) analysis, methylation-specific PCR (MSP), DNA sequencing, immunohistochemistry, and flow cytometry, we analysed expression and/or alteration of HLA class I antigen subunits and APM components, including low molecular weight polypeptide proteasome subunit (LMP)2, LMP7, LMP10, transporter associated with antigen processing (TAP)1, TAP2, tapasin, proteasome activator (PA) 28alpha, and PA28beta in two stage-matched panels of 30 MSI-H and 30 microsatellite stable (MSS) gastric cancers.
|
17318812 |
2007 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
In contrast, tapasin was normally transcribed in HLA-B44-positive colorectal tumors samples, as well as in 3 HLA-B44-negative laryngeal carcinomas and 1 bladder tumor.
|
15455354 |
2005 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In contrast, tapasin was normally transcribed in HLA-B44-positive colorectal tumors samples, as well as in 3 HLA-B44-negative laryngeal carcinomas and 1 bladder tumor.
|
15455354 |
2005 |
|
Juvenile-Onset Still Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that there is a weak association between systemic onset JRA and the TPSN polymorphism, possibly due to linkage disequilibrium with an as yet unknown susceptibility allele in the centromeric part of chromosome 6.
|
15743475 |
2005 |
|
Systemic onset juvenile chronic arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study.
|
15743475 |
2005 |
|
Juvenile rheumatoid arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We employed both a case-control approach and the transmission disequilibrium test, and found linkage and association between the TPSN allele (Arg260) and the systemic onset subtype of JRA.
|
15743475 |
2005 |
|
Secondary Neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The frequency of TAP1, LMP2 and tapasin loss varied between 33% of primary adenocarcinomas, 40% of HIN to approximately 67% of metastases.
|
14750179 |
2004 |