|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Significant lower ratio of CD3<sup>+</sup>CD4<sup>+</sup> T cells and higher ratio of CD8<sup>+</sup>IFN-γ<sup>+</sup> T cells were found in peripheral blood and tumor tissues in miR-570 mimics than NC.
|
29874097 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9.
|
26045791 |
2015 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Four miRNAs (miR-362-3p, miR-570, miR-148 a* and miR-944) were expressed at a higher level in tumors from patients with no recurrence (p<0.015), compared with tumors from patients with recurrence.
|
23280316 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
MicroRNA-34a (miR-34a), which is regulated by PI3K-mTOR signaling, plays a pivotal role in reducing sirtuin-1/6, and its inhibition with an antagomir results in their restoration, reducing markers of senescence, reducing senescence-associated secretory phenotype, and reversing cell cycle arrest in epithelial cells from peripheral airways of patients with COPD. miR-570 is also involved in reduction of sirtuin-1 and cellular senescence and is activated by p38 mitogen-activated protein kinase.
|
30860857 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of elevated miR-570-3p in COPD small airway epithelial cells, using an antagomir, restores sirtuin-1 and suppresses markers of cellular senescence (p16<sup>INK4a</sup>, p21<sup>Waf1</sup>, and p27<sup>Kip1</sup>), thereby restoring cellular growth by allowing progression through the cell cycle.
|
30156909 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The authors previously demonstrated that miR-570 regulates the development of HCC.
|
29874097 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The overexpression of B7-H1 reversed the inhibition of proliferation and invasion by miR-570.
|
26084609 |
2015 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In vitro studies further showed that miR-570 mimics could promote, while its antisense oligos inhibit cell proliferation and invasion.
|
26045791 |
2015 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hence, our observation confirmed that miR-570 works as proliferation and metastatic suppressor in hepatocellular carcinoma cells through directly targeting B7-H1 in hepatocellular carcinoma cell and rationally presents that miR-570 has the potential to be a useful clinical noninvasive diagnostics or predictive marker in human hepatocellular carcinoma.
|
26084609 |
2015 |
|
Neurosyphilis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In patients with neurosyphilis (NSP), miR-590-5p, miR-570-3p and miR-570-5p were upregulated in the CSF and serum, when compared with patients with syphilis without neurosyphilis (SP). miR-590-5p and miR-570-3p were significantly upregulated (p<0.001).
|
30926713 |
2019 |
|
Syphilis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In patients with neurosyphilis (NSP), miR-590-5p, miR-570-3p and miR-570-5p were upregulated in the CSF and serum, when compared with patients with syphilis without neurosyphilis (SP). miR-590-5p and miR-570-3p were significantly upregulated (p<0.001).
|
30926713 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results, for the first time, presents evidence that the miR-570-3p-mediated suppression of LCMR1 and ATG12 is involved in the metformin-induced inhibition of metastasis in osteosarcoma cells.
|
29795113 |
2018 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results, for the first time, presents evidence that the miR-570-3p-mediated suppression of LCMR1 and ATG12 is involved in the metformin-induced inhibition of metastasis in osteosarcoma cells.
|
29795113 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results, for the first time, presents evidence that the miR-570-3p-mediated suppression of LCMR1 and ATG12 is involved in the metformin-induced inhibition of metastasis in osteosarcoma cells.
|
29795113 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results, for the first time, presents evidence that the miR-570-3p-mediated suppression of LCMR1 and ATG12 is involved in the metformin-induced inhibition of metastasis in osteosarcoma cells.
|
29795113 |
2018 |
|
Myeloid Leukemia, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of miR-570 were significantly reduced in CML clinical samples and cells.
|
28656082 |
2017 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most notable associations were for hsa-miR-145-3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and hsa-miR-9-3p (HR 10.28, 95% CI 1.31, 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17, 95% CI 0.05, 0.54) for rectal cancer. hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site.
|
25484364 |
2015 |
|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A recent study reported that miR-570 was the most important microRNA in the microRNA gene networks of alcoholic liver disease that has the potential of progressing to hepatocellular carcinoma.
|
26084609 |
2015 |
|
Malignant neoplasm of gallbladder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population.
|
26288960 |
2015 |
|
Gallbladder Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population.
|
26288960 |
2015 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells.
|
26045791 |
2015 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells.
|
26045791 |
2015 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most notable associations were for hsa-miR-145-3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and hsa-miR-9-3p (HR 10.28, 95% CI 1.31, 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17, 95% CI 0.05, 0.54) for rectal cancer. hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site.
|
25484364 |
2015 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells.
|
26045791 |
2015 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population.
|
26288960 |
2015 |