ZEB1, zinc finger E-box binding homeobox 1, 6935

N. diseases: 310; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease CTD_human
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 CausalMutation disease CLINVAR
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0339284
Disease: Polymorphous corneal dystrophy
Polymorphous corneal dystrophy 		0.500 CausalMutation disease CLINVAR
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease CTD_human
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0010036
Disease: Corneal dystrophy
Corneal dystrophy 		0.140 CausalMutation disease CLINVAR
CUI: C0010036
Disease: Corneal dystrophy
Corneal dystrophy 		0.140 Biomarker disease HPO
CUI: C0019294
Disease: Hernia, Inguinal
Hernia, Inguinal 		0.110 Biomarker phenotype HPO
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.100 CausalMutation disease CLINVAR
CUI: C0022568
Disease: Keratitis
Keratitis 		0.100 Biomarker disease HPO
CUI: C0234632
Disease: Reduced visual acuity
Reduced visual acuity 		0.100 Biomarker phenotype HPO
CUI: C0271288
Disease: Corneal guttata
Corneal guttata 		0.100 Biomarker disease HPO
CUI: C0474444
Disease: Corneal stromal edema
Corneal stromal edema 		0.100 Biomarker phenotype HPO
CUI: C3665386
Disease: Abnormal vision
Abnormal vision 		0.100 CausalMutation phenotype CLINVAR
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.100 Biomarker disease BEFREE Among known transcriptional suppressors of E-cadherin, ZEB1 was uniquely correlated with E-cadherin loss in lung cancer cell lines, and its inhibition by RNA interference resulted in E-cadherin induction. 12937339 2003
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.100 Biomarker disease BEFREE Among known transcriptional suppressors of E-cadherin, ZEB1 was uniquely correlated with E-cadherin loss in lung cancer cell lines, and its inhibition by RNA interference resulted in E-cadherin induction. 12937339 2003
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker disease BEFREE Among known transcriptional suppressors of E-cadherin, ZEB1 was uniquely correlated with E-cadherin loss in lung cancer cell lines, and its inhibition by RNA interference resulted in E-cadherin induction. 12937339 2003
CUI: C0026010
Disease: Microphthalmos
Microphthalmos 		0.010 Biomarker disease BEFREE Tumors expressed S-100 protein (8 of 8), Melan-A (4 of 8), HMB-45 (8 of 8), and microphthalmia transcription factor (8 of 8) and lacked pancytokeratin (8 of 8) and smooth muscle actin (8 of 8). 15577676 2004
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis. 15674322 2005
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis. 15674322 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis. 15674322 2005
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.010 AlteredExpression disease LHGDN Defective binding of transcriptional repressor ZEB via DNA methylation contributes to increased constitutive levels of p73 in Fanconi anemia cells. 16087177 2005