ZEB1, zinc finger E-box binding homeobox 1, 6935

N. diseases: 310; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease CTD_human
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 CausalMutation disease CLINVAR
CUI: C2750448
Disease: CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0339284
Disease: Polymorphous corneal dystrophy
Polymorphous corneal dystrophy 		0.500 CausalMutation disease CLINVAR
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease CTD_human
CUI: C1836724
Disease: CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0010036
Disease: Corneal dystrophy
Corneal dystrophy 		0.140 CausalMutation disease CLINVAR
CUI: C0010036
Disease: Corneal dystrophy
Corneal dystrophy 		0.140 Biomarker disease HPO
CUI: C0019294
Disease: Hernia, Inguinal
Hernia, Inguinal 		0.110 Biomarker phenotype HPO
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.100 CausalMutation disease CLINVAR
CUI: C0022568
Disease: Keratitis
Keratitis 		0.100 Biomarker disease HPO
CUI: C0234632
Disease: Reduced visual acuity
Reduced visual acuity 		0.100 Biomarker phenotype HPO
CUI: C0271288
Disease: Corneal guttata
Corneal guttata 		0.100 Biomarker disease HPO
CUI: C0474444
Disease: Corneal stromal edema
Corneal stromal edema 		0.100 Biomarker phenotype HPO
CUI: C3665386
Disease: Abnormal vision
Abnormal vision 		0.100 CausalMutation phenotype CLINVAR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.100 Biomarker phenotype BEFREE <b>Background</b>: The reciprocal repressive loop between ZEB1 and miRNAs has been extensively reported to play an important role in tumor progression and metastasis of various human tumor types. 31534537 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE <b>Background</b>: The reciprocal repressive loop between ZEB1 and miRNAs has been extensively reported to play an important role in tumor progression and metastasis of various human tumor types. 31534537 2019
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.040 Biomarker disease BEFREE <b>Conclusion</b>: Our findings elucidated that copy number gains of ZEB1-triggered a TGF-β signaling-dependent miR-33a-5p-mediated negative feedback loop was highly relevant to the bone metastasis of PCa. 31534537 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.100 Biomarker disease BEFREE <b>Conclusion</b>: Our findings elucidated that copy number gains of ZEB1-triggered a TGF-β signaling-dependent miR-33a-5p-mediated negative feedback loop was highly relevant to the bone metastasis of PCa. 31534537 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.100 Biomarker disease BEFREE <b>Conclusion</b>: Our findings elucidated that copy number gains of ZEB1-triggered a TGF-β signaling-dependent miR-33a-5p-mediated negative feedback loop was highly relevant to the bone metastasis of PCa. 31534537 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.390 Biomarker disease BEFREE <b>Conclusions:</b> As both Snail and ZEB1 are crucial inducers of epithelial-to-mesenchymal transition (EMT), our data suggested that CD44 may be crucial for the EMT process of ovarian cancer. 31497537 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.380 Biomarker disease BEFREE <b>Conclusions:</b> As both Snail and ZEB1 are crucial inducers of epithelial-to-mesenchymal transition (EMT), our data suggested that CD44 may be crucial for the EMT process of ovarian cancer. 31497537 2019
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.100 Biomarker disease BEFREE <b>Conclusions:</b> As both Snail and ZEB1 are crucial inducers of epithelial-to-mesenchymal transition (EMT), our data suggested that CD44 may be crucial for the EMT process of ovarian cancer. 31497537 2019