|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, in the proper clinicopathologic setting, and with consideration of the known limitations of this technique, TCR gene rearrangement studies on lesional skin using PCR may be helpful as an adjunct to the histopathologic diagnosis of MF.
|
10535585 |
1999 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The TCR gene rearrangement imprint is a stable and reliable tumour marker of MF disease.
|
12588378 |
2003 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
We used the amplification of junctional V (variable)-J joining sequences of the rearranged T-cell receptor gamma (TCR gamma) genes by polymerase chain reaction for rapid and sensitive detection of a clonal T-cell population in a total of 51 skin specimens obtained from 45 patients with mycosis fungoides, five patients with Sézary syndrome, and 29 patients with chronic inflammatory dermatoses.
|
7661604 |
1995 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The testable inference of the mature T-cell theory is the clonality of MF with respect to all rearranged T-cell receptor (TCR) genes.
|
31515249 |
2019 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Little information is currently available regarding post-treatment outcome of TCR-targeted PCR in skin and/or peripheral blood in patients with Mycosis Fungoides (MF) when a dominant gene rearrangement is present at time of diagnosis.
|
12925223 |
2003 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The few studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anatomic sites in MF have generally reported a common clone.
|
12384439 |
2002 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
As T cell receptor gamma-chain polymerase chain reaction GeneScan analysis (TCR-gamma-PCR-GSA) stands out by its sensitivity, its accuracy in size determination of PCR products, its capacity to identify false positives by repeated analysis and its easy applicability, this approach was used to analyse the clonality status of 41 patients with borderline T cell lymphoproliferative skin diseases, including parapsoriasis (n=27) and early-stage mycosis fungoides (MF) (n=14).
|
12115881 |
2002 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
However, TCRG gene rearrangement studies by means of TCR-TGGE analysis may be useful for distinguishing histologically discordant cases of initial MF.
|
11323219 |
2001 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The results of this study indicate that within the group of dermatopathic MF lymph nodes, prognostically different groups can be distinguished and that TCR beta gene rearrangement analysis may be an important adjunct in the early diagnosis of lymph node involvement by MF.
|
8133398 |
1993 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
T-cell deletion and T-cell receptor (TCR) gene rearrangement studies are helpful in the early diagnosis and subsequent management of mycosis fungoides (MF).
|
11511839 |
2001 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
CD13 and TCR clone: markers of early mycosis fungoides.
|
17340024 |
2007 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated the clinicopathological features, T-cell receptor (TCR) gene rearrangement findings, treatment and follow up in childhood MF.
|
19583687 |
2009 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate that TCR gene clonal rearrangement analysis is a useful tool in diagnosing early MF.
|
21439248 |
2011 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we have successfully adopted targeted whole-exome sequencing (WES) to identify the repertoire of rearranged TCR genes in tumor-enriched samples from patients with MF.
|
30967393 |
2019 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Gains of TCRB and TCRG genes were observed in 23% (3 of 13) of SS and 50% (3 of 6) of MFt, reflecting the presence of trisomy and/or tetrasomy of chromosome 7 already detected by conventional cytogenetics and array comparative genetic hybridization techniques.
|
21872828 |
2011 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Clonal TCR gamma gene rearrangements were found in 66% of patch/plaque-stage MF and 100% of tumor-stage MF and pleomorphic CTCL, but not in any of 10 pseudo-T-cell lymphomas studied.
|
9176388 |
1997 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
There is limited information regarding the performance characteristics and utility of TCRG and TCRB clonality assays in diagnosis of MF and ID from paraffin-embedded tissue sections.
|
20203005 |
2010 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Cutaneous biopsies from 68 patients were histologically diagnosed as MF and T-cell clonality was analyzed by in vitro amplification of TCR-gamma chain gene rearrangements (polymerase chain reaction gamma [PCRgamma]).
|
9787176 |
1998 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
A retrospective chart review was used to select patients with a diagnosis of MF who had a skin biopsy and a positive TCR gene rearrangement study in either blood or tissue and at least 2 years of clinical follow-up.
|
30171087 |
2018 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
With respect to dermatology, the knowledge of TCR genetics, along with the application of recombinant DNA methodology, has provided a major improvement in the diagnosis and management of mycosis fungoides.
|
2249358 |
1990 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Only one patient with MF had a rearrangement of gamma and delta with germ line beta TCR genes.
|
1654197 |
1991 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Molecular staging in MF and SS using a PCR-based method for TCR gene analysis provides additional information to histological examination.
|
16965425 |
2006 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The strategy of multiple PCR/heteroduplex analysis for TCR-γ gene rearrangement combined with LCM increases the detection rate of clonal TCR-γ gene rearrangement in early MF cases and could provide strong evidence to confirm the diagnosis of early MF.
|
22335593 |
2012 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings indicate that in LPP TCR gene rearrangement status has no prognostic significance and does not allow distinction of LPP and early MF.
|
10678699 |
2000 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |