|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Pre- and posttreatment biopsies from 20 lesional skin samples of 18 patients with mycosis fungoides who received either 8 Gy LDRT (<i>n</i> = 16) or topical steroids (<i>n</i> = 4) underwent high-throughput T-cell receptor sequencing of the TCRB gene to quantify the malignant T-cell clone.
|
31636100 |
2020 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The testable inference of the mature T-cell theory is the clonality of MF with respect to all rearranged T-cell receptor (TCR) genes.
|
31515249 |
2019 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we have successfully adopted targeted whole-exome sequencing (WES) to identify the repertoire of rearranged TCR genes in tumor-enriched samples from patients with MF.
|
30967393 |
2019 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
A retrospective chart review was used to select patients with a diagnosis of MF who had a skin biopsy and a positive TCR gene rearrangement study in either blood or tissue and at least 2 years of clinical follow-up.
|
30171087 |
2018 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The strategy of multiple PCR/heteroduplex analysis for TCR-γ gene rearrangement combined with LCM increases the detection rate of clonal TCR-γ gene rearrangement in early MF cases and could provide strong evidence to confirm the diagnosis of early MF.
|
22335593 |
2012 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate that TCR gene clonal rearrangement analysis is a useful tool in diagnosing early MF.
|
21439248 |
2011 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Gains of TCRB and TCRG genes were observed in 23% (3 of 13) of SS and 50% (3 of 6) of MFt, reflecting the presence of trisomy and/or tetrasomy of chromosome 7 already detected by conventional cytogenetics and array comparative genetic hybridization techniques.
|
21872828 |
2011 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
There is limited information regarding the performance characteristics and utility of TCRG and TCRB clonality assays in diagnosis of MF and ID from paraffin-embedded tissue sections.
|
20203005 |
2010 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated the clinicopathological features, T-cell receptor (TCR) gene rearrangement findings, treatment and follow up in childhood MF.
|
19583687 |
2009 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
CD13 and TCR clone: markers of early mycosis fungoides.
|
17340024 |
2007 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Molecular staging in MF and SS using a PCR-based method for TCR gene analysis provides additional information to histological examination.
|
16965425 |
2006 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
The TCR gene rearrangement imprint is a stable and reliable tumour marker of MF disease.
|
12588378 |
2003 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Little information is currently available regarding post-treatment outcome of TCR-targeted PCR in skin and/or peripheral blood in patients with Mycosis Fungoides (MF) when a dominant gene rearrangement is present at time of diagnosis.
|
12925223 |
2003 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The few studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anatomic sites in MF have generally reported a common clone.
|
12384439 |
2002 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
As T cell receptor gamma-chain polymerase chain reaction GeneScan analysis (TCR-gamma-PCR-GSA) stands out by its sensitivity, its accuracy in size determination of PCR products, its capacity to identify false positives by repeated analysis and its easy applicability, this approach was used to analyse the clonality status of 41 patients with borderline T cell lymphoproliferative skin diseases, including parapsoriasis (n=27) and early-stage mycosis fungoides (MF) (n=14).
|
12115881 |
2002 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
However, TCRG gene rearrangement studies by means of TCR-TGGE analysis may be useful for distinguishing histologically discordant cases of initial MF.
|
11323219 |
2001 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
T-cell deletion and T-cell receptor (TCR) gene rearrangement studies are helpful in the early diagnosis and subsequent management of mycosis fungoides (MF).
|
11511839 |
2001 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Four biopsies, from three patients, contained clonal TCR-gamma rearrangements; the four biopsies, all of which were equivocal histologically, correlated to diagnoses of mycosis fungoides (MF) or Sézary syndrome (SS).
|
11437940 |
2001 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings indicate that in LPP TCR gene rearrangement status has no prognostic significance and does not allow distinction of LPP and early MF.
|
10678699 |
2000 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
A fifth patient is reported who had hypopigmented mycosis fungoides and classical Pautrier microabscesses, for whom no TCR gene rearrangement analysis was performed.
|
11003719 |
2000 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, in the proper clinicopathologic setting, and with consideration of the known limitations of this technique, TCR gene rearrangement studies on lesional skin using PCR may be helpful as an adjunct to the histopathologic diagnosis of MF.
|
10535585 |
1999 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Cutaneous biopsies from 68 patients were histologically diagnosed as MF and T-cell clonality was analyzed by in vitro amplification of TCR-gamma chain gene rearrangements (polymerase chain reaction gamma [PCRgamma]).
|
9787176 |
1998 |
|
Mycosis Fungoides
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our purpose was to evaluate the role of immunophenotyping and T-cell receptor (TCR) gene rearrangement studies as an adjunct to the histopathologic diagnosis of MF.
|
9777761 |
1998 |
|
Mycosis Fungoides
|
0.100 |
Biomarker
|
group |
BEFREE |
Lymph node TCRB gene analysis provides additional prognostic information for patients with mycosis fungoides with intermediate LN histopathology.
|
9487207 |
1998 |