TERF2, telomeric repeat binding factor 2, 7014

N. diseases: 125; N. variants: 4
Disease: Superficial ulcer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333307
Disease: Superficial ulcer
Superficial ulcer 		0.020 Biomarker disease BEFREE The telomeric protein TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine. 18025071 2008
CUI: C0333307
Disease: Superficial ulcer
Superficial ulcer 		0.020 AlteredExpression disease BEFREE In cultured cardiomyocytes, interference with either TRF2 function or expression triggered telomere erosion and apoptosis, indicating that cell death can occur via this pathway even in postmitotic, noncycling cells; conversely, exogenous TRF2 conferred protection from oxidative stress. 12702777 2003