TFRC, transferrin receptor, 7037

N. diseases: 359; N. variants: 40
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 AlteredExpression disease BEFREE The transferrin receptor is overexpressed on the surface of glioblastoma cells, and T7 is a transferrin receptor-binding peptide. 31730913 2020
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE As expected, the developed chimeric structure efficiently delivered the antimiRzyme RNV541 into TfR positive glioblastoma cells. 31284665 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE GaM also inhibited iron uptake and upregulated TfR1 expression in U-87 MG and D54 cells <i>in vitro</i> We conclude that GaM enters the brain via TfR1 on BMECs and targets iron metabolism in glioblastoma <i>in vivo,</i> thus inhibiting tumor growth. 29592883 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.040 Biomarker disease BEFREE The functionalization with the monoclonal antibody for transferrin receptor proved to be advantageous in enhancing the cellular internalization in glioblastoma cells. 29715532 2018