|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Additionally, TSH regulates post-translational changes in thyroglobulin that selectively enhance its capacity for T<sub>3</sub> formation - this process is important in iodide deficiency and in Graves disease.
|
30886364 |
2019 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Their unanticipated expression of several proteins traditionally thought to be thyroid gland specific, including the TSH receptor and thyroglobulin, may underlie orbital involvement in Graves disease.
|
30445529 |
2019 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The fine mapping study of thyroglobulin identified two independent SNPs (rs2294025 and rs7005834) for GD susceptibility.
|
31700870 |
2019 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thyroglobulin (TG) is a major susceptibility gene for both Graves disease and Hashimoto thyroiditis.
|
30113675 |
2018 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, TG secreted from human thyrocyte cultures hyperstimulated with TSH also showed an increased intrinsic ability to form T<sub>3</sub> Our data support the hypothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alters the structure of the iodination substrate in a way that enhances <i>de novo</i> T<sub>3</sub> formation, contributing to the relative T<sub>3</sub> toxicosis of Graves' disease.
|
28743746 |
2017 |
|
Graves Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
SNPs in the TG gene were associated with the development of HD and GD, the intractability of GD, and the levels of TG mRNA expression, serum TG, and serum TgAb.
|
28675712 |
2017 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
To this purpose, we will firstly focus our attention on the role of genetic factors (the HLA complex, the genes encoding for thyroglobulin, the TSH receptor, CD40, CTLA-4 and PTPN22), and of environmental factors (iodine, infections, psychological stress, gender, smoking, thyroid damage, vitamin D, selenium, immune modulating agents) as possible causes of BD.
|
26293122 |
2015 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
|
23612905 |
2013 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
|
23612905 |
2013 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our observations establish the basis for Tg accumulation in orbital GD.
|
22517745 |
2012 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In total, 5 SNPs revealed association with GD (P<0.05), with the strongest SNP associations at rs2256366 (P = 0.002) and rs2687836 (P = 0.0077), both located in intron 41 of the Tg gene.
|
22662162 |
2012 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
TSH and thyroglobulin (Tg) effects on pendrin expression were investigated by immunofluorescence on primary cell culture from GD thyroid tissues.
|
21035230 |
2011 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The prevalence of autoimmune thyroid disease, including Hashimoto's thyroiditis and Graves' disease, has provided the impetus for identifying pathogenic T cell epitopes from human Tg over two decades.
|
21683551 |
2011 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In Graves' disease a specific combination of polymorphisms for thyroglobulin and HLA-DR markedly increases the odds ratio for developing disease.
|
19474733 |
2009 |
|
Graves Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Following lymphocyte stimulation, Tg mRNA levels were observed to be increased 2.7-fold in Graves' disease and 1.6-fold in chronic thyroiditis compared to healthy subjects.
|
18243140 |
2008 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there is increasing evidence for a genetic interaction between thyroglobulin variants and DRb1-Arg74 in conferring risk for GD.
|
18178059 |
2008 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it.
|
18385936 |
2008 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the association of TG and CD40 polymorphisms with age at onset of GD in Taiwanese patients.
|
18755875 |
2008 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of family data did not show linkage of the thyroglobulin gene with AITD nor did analysis of case-control data show association of Tgms2 or SNPs with GD.
|
18656705 |
2008 |
|
Graves Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that AJBHT might suppress T(4) synthesis by modulating adenosine 3',5'-cyclic monophosphate (cAMP) and Tg expression, and therefore, AJBHT could be an alternative therapy for Graves' disease patients who have side effects from antithyroid drugs.
|
18379045 |
2008 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies.
|
17823263 |
2007 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether Tg single nucleotide polymorphisms (SNPs) relate to GD development in a Taiwanese population.
|
17550957 |
2007 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Subset analysis of patients with persistently elevated thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies (Abs), (TPO/Tg Abs), after treatment (n=126), revealed a significantly stronger association of the SNP with disease (P=5.2 x 10(-5), OR=2.5) than in GD patients who were thyroid antibody-negative.
|
17344890 |
2007 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have identified four subset-specific AITD loci, and two putative subset-specific AITD susceptibility genes; the FOXP3 gene in juvenile GD and the thyroglobulin gene in females with AITD.
|
17644307 |
2007 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal.
|
17526951 |
2006 |