Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Asthma model was induced using ovalbumin (OVA) method and AMSC hyperplasia model was induced using TGF-β1.
|
31733831 |
2020 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we assessed whether TGF-β1 affects the ability of HASM cells to relax in response to β<sub>2</sub>-agonists, a mainstay treatment for airway hyperresponsiveness in asthma.
|
30742476 |
2019 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Among elderly asthmatics, subjects with severe asthma had lower FEV1 (% predicted) value, but showed significantly higher serum levels of eotaxin-2 and TGF-β1, than those with non-severe asthma (<i>P</i> < 0.05 for each).
|
30479079 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, the present results have revealed that PCA inhibits asthma airway remodeling by suppressing proliferation and extracellular matrix (ECM) protein deposition in TGF-β1-mediated ASMCs via the inactivation of Smad2/3 signaling pathway.
|
30472056 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
MicroRNA-744 Inhibits Proliferation of Bronchial Epithelial Cells by Regulating Smad3 Pathway via Targeting Transforming Growth Factor-β1 (TGF-β1) in Severe Asthma.
|
30903795 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the current study, we found that miR-448-5p was dramatically decreased in lung tissues of asthmatic mice and TGF-β1-stimulated bronchial epithelial cells.
|
30362537 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma.
|
31780948 |
2019 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Immunofluorescence showed that ROS and TGF-β1 expression was significantly increased in lung tissue from the OVA-induced asthma model.
|
30092299 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
It will further review the evidence demonstrating the extent to which IL-17A interacts with various immune factors, specifically TGF-β1, to contribute to ASM remodeling and altered function in T<sub>H</sub>17-driven endotypes of severe asthma.
|
30810068 |
2019 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The exhaled-TGF-β1 levels were significantly lower in those children with asthma exacerbation when compared to the stable asthmatic children (<i>p</i> = 0.0003).<b>Conclusion:</b> Our results suggest that TGF-β1 may play a role in suppressing airway reactivity and its deficiency is associated with asthma exacerbation.AbbreviationsACTAsthma control testAHRAirway hyper-reactivityASMAirway smooth muscleBALBronchoalveolar lavageELISAEnzyme-linked immunoassayEIBExercise-induced bronchospasmEBCExhaled breath condensateFEV1Forced expiratory volume in the first secondFEV1/FVCForced expiratory volume in the first second/forced vital capacityFEF25%-75%Forced expiratory flow, midexpiratory phaseGINAGlobal Initiative for Asthma(Ig)EImmunoglobulin EISAACInternational Study of Asthma and Allergies in ChildhoodIQRInterquartile rangeIL-10Interleukin-10TGF-β1Transforming growth factor-β1Treg cellsT regulatory cells.
|
31709879 |
2019 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the results suggested that TGF-β1 enhances ADAM33 expression in airway epithelial cells, and that ADAM33 induces the EMT of airway epithelial cells, thus participating in airway remodeling in asthma.
|
29399106 |
2018 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results demonstrate that SIRT7 is involved in regulating TGF-β1-induced ASM cell proliferation and migration by regulating the expression of TβRI, thus indicating an important role of SIRT7 during airway remodeling in asthma.
|
29843083 |
2018 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma.
|
29343695 |
2018 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, the role of TGF-β1 in excessive airway narrowing in asthma, or airway hyperresponsiveness (AHR), remains unclear.
|
28984468 |
2018 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results showed that RAGE inhibition or RAGE knockdown decreased β-catenin nuclear accumulation and the expression of relevant β-catenin targeted genes (VEGF, MMP9, TGF-β1) in the TDI-induced murine asthma model and TDI-HSA-treated 16HBE cells, respectively.
|
29656209 |
2018 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found significantly decreased Bcl11b but increased IL-17A and TGF-β1 expression in patients with asthma and a strongly negative correlation between Bcl11b and these 2 cytokines in SA patients.
|
30088373 |
2018 |
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this meta-analysis was to evaluate the relation of two transforming growth factor-β1 (TGF-β1) polymorphisms with asthma risk in Chinese population.
|
29958018 |
2018 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children.
|
28262390 |
2018 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation.
|
28284979 |
2017 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TGF-β1 is an important cytokine in airway remodeling in asthma.
|
27905842 |
2017 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A total of 58 asthmatic patients (33 with severe refractory asthma (SRA)) and 10 healthy controls underwent sputum induction for % cells, activin A, follistatin, eosinophilic cationic protein (ECP), transforming growth factor beta 1 (TGF-β1), IL-13 and IL-8 measurements.
|
27807906 |
2017 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Ovalbumin induced rat asthma model and TGF-β1-induced BEAS-2B cell apoptosis model were established, respectively.
|
27916734 |
2017 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Through our review, we aim to further elucidate the role of TGF-β1 in asthma pathogenesis and the link between airway remodeling and airway hyperresponsiveness in asthma and to define TGF-β1 as a potential therapeutic target for reducing asthma morbidity and mortality.
|
27854509 |
2017 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to evaluate the effect of TGF-β1 mRNA expression on IL-15 mRNA expression in asthmatic patients and to assess the role of IL-15 in the clinical course of asthma.
|
29104662 |
2017 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
GSDMB regulates expression of 5-LO and TGF-β1 which are known pathways involved in the pathogenesis of asthma.
|
28826527 |
2017 |