Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Taken together, our study indicates that Smad2/3/SphK1/S1P/Notch3 pathway mediates TGF-β1-induced PASMC proliferation and suggests this pathway as a potential therapeutic target in the prevention and treatment of pulmonary hypertension.
|
30430898 |
2020 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We found that OSA combined with HSD increased the severity of hypertension through increasing level of blood Trimethylamine-Oxide (TMAO), release of Th1-related cytokine (IFN-γ) and inhibition of anti-inflammatory cytokine (TGF-β1), and affected the gut microbiome in rats, particularly by depleting Lactobacillus.
|
30784906 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats.
|
31254954 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The expression of TGF-β1 was significantly elevated, whereas the expression of PI3KC3 was significantly downregulated in the patients with hypertension compared with controls.
|
30783440 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
MiR-21 regulates pulmonary hypertension in rats via TGF-β1/Smad2 signaling pathway.
|
31115027 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension.
|
29976656 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It was concluded that the the MRs-redox signalling pathway is involved in TGF-β1-induced renal tubular EMT and renal inflammation/fibrosis in AngII-induced hypertension.
|
29863758 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Transforming growth factor‑β1 (TGF‑β1)/small mothers against decapentaplegic 3 (Smad3) is considered a potential therapeutic target for vascular remodeling in hypertension.
|
28791353 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Heart tissue was analyzed by histopathological morphometry, including assessments of ventricular and coronary vascular hypertrophy and fibrosis, as well as immunohistochemistry analyses of myocardial expression of AT<sub>1</sub>R. l-NAME treatment reduced the plasma nitrate level and led to the development of hypertension, with increased plasma levels of AT II and increased heart transcriptional levels of AT<sub>1</sub>R and TGF-β1-mediated connective tissue proteins, showing myocardial and coronary arteriolar hypertrophy and fibrosis.
|
28438687 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The present study tested the hypothesis whether elevated TGF-β1 levels can predict the development of hypertension.
|
28575138 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
GSPE decreased oxidative stress associated with hypertension in SHR and suppressed the increased expression of TGF‑β1, which blocked the translocation and differentiation of adventitia fibroblasts and eventually inhibited collagen hyperplasia in the blood vessel.
|
28447711 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways.
|
27297622 |
2016 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
TGFB1 rs1800469 polymorphism was observed to be associated with IA through co-modifying factors such as hypertension and gender.
|
26198819 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Hypertension was associated with the CC genotype and C allele for IL-10 -592C/A polymorphism (p = 0.013 and p = 0.009) and higher frequencies of T (p = 0.047) and C (p = 0.033) alleles of the TGF-β1 codon 10T/C and IL-10 -819T/C polymorphisms, respectively.
|
26064986 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We assessed the association between 5 well-defined polymorphisms of the transforming growth factor-β1 (TGFB1) gene and coronary artery disease (CAD) among patients with hypertension from northeast China.
|
25155040 |
2015 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1, and VCAM1 and decreased expression of SELPLG and SERPINEB2.
|
23337395 |
2014 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Normally distributed square root of TGF-β1 (pg/ml) of hypertension cases (148.56 ± 66.46) was significantly higher than that of control (128.52 ± 65.11), P = 0.008.
|
24413999 |
2014 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Conversely, P311-transgenic (P311(TG)) mice had elevated levels of TGF-β1-TGF-β3 and subsequent hypertension.
|
24091331 |
2013 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this study, the authors performed a meta-analysis to investigate the associations of +869T/C and +915G/C polymorphisms in TGF-β1 gene with hypertension risk in Chinese.
|
22209986 |
2012 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF-α neutralization reduced hypertension, albuminuria and renal inflammation and fibrosis, which were coupled to a reduction in renal NF-ĸB activation, inflammatory markers expression, TGF-β1 and ET-1 production, and an increase in NO release.
|
22813949 |
2012 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our data provide evidence that calpain mediates EGF- and PDGF-induced collagen synthesis and proliferation of pulmonary artery smooth muscle cells via an intracrine TGF-β1 pathway in pulmonary hypertension.
|
22005303 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
TGF-beta(1) may cause endothelial dysfunction in apolipoprotein E-deficient (apoE(-/-)) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart remodeling and hypertension.
|
20511416 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In some, but not all, studies, IL6 -174G/C (rs1800795) and TGFB1 869T/C (rs1982073) gene polymorphisms have been associated with hypertension in the general population.
|
19106168 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways.
|
19018797 |
2009 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome.
|
18097622 |
2008 |