Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of transforming growth factor-β1 and α-smooth muscle actin contributes to the protection of lotensin against chronic renal failure in rats.
|
30371125 |
2018 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Aims/Hypothesis:</b> Transforming growth factor-beta (TGF-β1) plays an important regulatory role in the progression of chronic kidney failure.
|
30618784 |
2018 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggested that osthole protects against inflammation in a rat model of CRF via suppression of NF‑κB and TGF‑β1, and activation of PI3K/Akt/nuclear factor (erythroid‑derived 2)‑like 2 signaling.
|
28765904 |
2017 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir.
|
25871499 |
2015 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study is the first prospective study to demonstrate that circulating TGF-β1-regulated miRNAs are deregulated early in T1D patients who are at risk for rapid progression to ESRD.
|
25931475 |
2015 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mean TGF-β1 protein levels were 2.7-fold lower in ESRD patients as compared to normal controls (p<0.001).
|
24113078 |
2014 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phosphorylated NF-κB p65 was expressed and colocalized with p53, p21, β-galactosidase, TGF-β1, and α-SMA in the kidneys of chronic renal failure (CRF) rats.
|
21832251 |
2011 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
CTD_human |
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure.
|
19420110 |
2009 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis.
|
17173255 |
2007 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation.
|
17198270 |
2006 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation.
|
17198270 |
2006 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency.
|
15942255 |
2005 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort.
|
15593053 |
2005 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort.
|
15593053 |
2005 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Low TGF-beta1 serum levels are a risk factor for atherosclerosis disease in ESRD patients.
|
11786115 |
2002 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
RGD |
Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate.
|
10919844 |
2000 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta1 (TGF-beta1) may play a major role in the pathogenesis of glomerulopathy and end-stage renal disease (ESRD).
|
11140698 |
2000 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
(The use of ESRD patients as the study cohort eliminates renal function-dependent alterations in circulating levels of TGF-beta1 protein.)
|
9931116 |
1999 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our observation that TGF-beta 1 is hyperexpressed in black ESRD patients suggests a mechanism for the increased prevalence of renal failure (since TGF-beta 1 hyperexpression can result in renal insufficiency in experimental models) among the black population.
|
9507209 |
1998 |