TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Disease: Renal Insufficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease BEFREE Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway. 29549584 2018
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease BEFREE We confirmed our observations through MSCs or MSC-EVs treatment alleviated hydronephrosis, less renal dysfunction and blunted transforming growth factor-β1 induced fibration. 29993184 2018
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE This study examined the levels of serum Fas ligand (FasL), serum myostatin and urine transforming growth factor-beta 1 (TGF-β1) and their association with markers of endothelial dysfunction, in ADPKD patients with preserved or impaired renal function. 29794429 2018
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE We conclude that polymorphisms in the genes encoding TGFB1 and CAV1 previously associated with the development and progression of fibrosis in several organ systems are not associated with development of NSF in this cohort of patients with renal impairment after GCCA exposure. 23051628 2013
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in the transforming growth factor-β1 gene (TGFB1) have been inconsistently associated with calcineurin inhibitor (CNI)-induced renal dysfunction following cardiac transplantation. 22322241 2012
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE Few studies investigated polymorphisms in the TGF-beta1 and TGF-beta3 genes in relation to renal dysfunction in non-diabetic subjects. 18293167 2008
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 AlteredExpression disease BEFREE There was no correlation between baseline MMP-2/MMP-9/TIMP-1/TGF-beta1 levels and the degree of renal dysfunction or with progression toward ESRD. 17205957 2007
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease BEFREE We hypothesized that transforming growth factor beta1 (TGFbeta1) might play a role in the fibrogenic mechanisms leading to renal dysfunction. 15694998 2005
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease BEFREE Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency. 15942255 2005
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE In our study, we have demonstrated the prognostic significance of TGF beta I gene polymorphism for renal insufficiency in heart transplant recipients. 11803605 2001
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 GeneticVariation disease BEFREE For the TGF-beta1 codon 25 genotypes, we found no association between TGF-beta 1 genotypes and renal dysfunction. 11008076 2000
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease BEFREE Our observation that TGF-beta 1 is hyperexpressed in black ESRD patients suggests a mechanism for the increased prevalence of renal failure (since TGF-beta 1 hyperexpression can result in renal insufficiency in experimental models) among the black population. 9507209 1998